Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 11  |  Issue : 41  |  Page : 123--130

Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species


Marcelo de Almeida Pinheiro1, Rafael Matos Magalhães1, Danielle Mesquita Torres1, Rodrigo Cardoso Cavalcante1, Francisca Sheila Xavier Mota1, Emanuela Maria Ara˙jo Oliveira Coelho1, Henrique Pires Moreira1, Glauber Cruz Lima2, Pamella Cristina da Costa Ara˙jo2, José Henrique Leal Cardoso2, Andrelina Noronha Coelho de Souza2, Lúcio Ricardo Leite Diniz1 
1 Department of Medical Sciences, Faculty of Medicine, Centro Universitário Unichristus, Fortaleza, CE, Brazil
2 Department of Physiology, Superior Institute of Biomedical Sciences, University of Ceará, Fortaleza, CE, Brazil

Correspondence Address:
Lúcio Ricardo Leite Diniz
Department of Medical Sciences, Faculty of Medicine, Centro Universitário Unichristus, Rua João Adolfo Gurgel, 133, 60192-345, Fortaleza, CE
Brazil

Background: Alpha-pinene (α-pinene) is a monoterpene commonly found in essential oils with gastroprotective activity obtained from diverse medicinal plants, including Hyptis species. The genus Hyptis (lamiaceae) consists of almost 400 species widespread in tropical and temperate regions of America. In the north and northeastern Brazil, some Hyptis species are used in traditional medicine to treat gastrointestinal disturbances. Objective: The present study has investigated the gastoprotective effect of purified α-pinene in experimental gastric ulcer induced by ethanol and indomethacin in mice. Materials and Methods: Gastric ulcers were induced in male Swiss mice (20-30 g) by oral administration of absolute ethanol or indomethacin 45 min after oral pretreatment with vehicle, standard control drugs or α-pinene (10, 30, and 100 mg/kg). One hour after the ulcerative challenges, the stomach were removed, and gastric lesions areas measured. The effects of α-pinene on the gastric juice acidity were determined by pylorus ligation model. The gastrointestinal motility and mucus depletion were determined by measuring the gastric levels of phenol red and alcian blue, respectively. Hematoxylin and eosin stained sections of gastric mucosa of the experimental groups were used for histology analysis. Results: α-pinene pretreatment inhibited ethanol-induced gastric lesions, reduced volume and acidity of the gastric juice and increased gastric wall mucus (P < 0.05). Furthermore, we showed an interesting correlation between concentration of α-pinene and gastroprotective effect of Hyptis species (P Pearson = 0.98). Conclusion: Our data showed that the α-pinene exhibited significant antiulcerogenic activity and a great correlation between concentration of α-pinene and gastroprotective effect of Hyptis species was also observed.


How to cite this article:
Pinheiro Md, Magalhães RM, Torres DM, Cavalcante RC, Mota FS, Oliveira Coelho EM, Moreira HP, Lima GC, da Costa Ara˙jo PC, Cardoso JH, de Souza AN, Diniz LR. Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species.Phcog Mag 2015;11:123-130


How to cite this URL:
Pinheiro Md, Magalhães RM, Torres DM, Cavalcante RC, Mota FS, Oliveira Coelho EM, Moreira HP, Lima GC, da Costa Ara˙jo PC, Cardoso JH, de Souza AN, Diniz LR. Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species. Phcog Mag [serial online] 2015 [cited 2022 May 27 ];11:123-130
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2015;volume=11;issue=41;spage=123;epage=130;aulast=Pinheiro;type=0