Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 10  |  Issue : 38  |  Page : 217--224

Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicity


Eda Ozcelik1, Sema Uslu2, Dilek Burukoglu3, Ahmet Musmul4 
1 Department of Nutrition and Dietetics, Healthy Sciences, Artvin Coruh University, Artvin, Turkey
2 Department of Biochemistry, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey
3 Department of Histology and Embryology, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey
4 Department of Biostatistics, Eskisehir Osmangazi University, School of Medicine, Eskisehir, Turkey

Correspondence Address:
Eda Ozcelik
Department of Nutrition and Dietetics, Faculty of Healthy Sciences, Artvin Coruh University, Artvin
Turkey

Background: Liver diseases have become a major problem of the worldwide. More than 50% of all cases of liver failure can be attributed to drugs. Among these, acetaminophen is the most common cause. Objective: The aim of this study was to investigate the the hepatoprotective effects of blueberry and chitosan on tissue arginase activity, ornithine and nitric oxide levels during the acetaminophen-induced hepatotoxicity. Materials and Methods: Acetaminophen (250 mg/kg body weight per day), blueberry (60 mg/kg body weight per day) and, chitosan (200 mg/kg body weight per day) were administered to the rats by oral gavage during the experimental period. Results: Blueberry and chitosan significantly decreased liver arginase activity and ornithine levelsand and increased nitric oxide levels. Glutathione levels were remarkably increased by chitosan and blueberry treatments. Conclusion: The results of the present study indicate that blueberry and chitosan effectively protected against the acetaminophen-induced hepatotoxicity. The hepatoprotective effect afforded by blueberry and chitosan can be attributed to its antioxidant and anti-inflammatory activities.


How to cite this article:
Ozcelik E, Uslu S, Burukoglu D, Musmul A. Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicity.Phcog Mag 2014;10:217-224


How to cite this URL:
Ozcelik E, Uslu S, Burukoglu D, Musmul A. Chitosan and blueberry treatment induces arginase activity and inhibits nitric oxide production during acetaminophen-induced hepatotoxicity. Phcog Mag [serial online] 2014 [cited 2021 Jun 23 ];10:217-224
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2014;volume=10;issue=38;spage=217;epage=224;aulast=Ozcelik;type=0