Year : 2012 | Volume
: 8 | Issue : 30 | Page : 98--102
Chemical constituents with free-radical-scavenging activities from the stem of Fissistigma polyanthum
Hua Fan1, Tong Zheng1, Yu Chen2, Guang-Zhong Yang1
1 Department of Natural Products, College of Pharmacy, South Central University for Nationalities, Wuhan, P.R., China
2 College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan, P.R, China
Background: Fissistigma polyanthum is a liane belonging to the Annonaceae family and it is one of the most important crude drugs in traditional Chinese medicine. Objective: The objective was to describe the structural elucidation and the free-radical-scavenging activities of the isolated compounds from Fissistigma polyanthum. Material and Methods: The chemical constituents were isolated and purified by normal, reverse column chromatography and HPLC. Their structures were identified by spectroscopic methods ( 1 H NMR and 13 C NMR) and by comparison with literature values, and the free-radical-scavenging activities of these two compounds were also evaluated through three in vitro model systems (DPPH, trolox equivalent antioxidant capacity (TEAC) and Co (II) EDTA-induced luminol chemiluminescence by flow injection). Results: Two known compounds, named kanakugiol (1) and teutenone A (2), were isolated from the stem of Fissistigma polyanthum for the first time, and compound 1 exhibited moderate free-radical-scavenging activity. Conclusion: Fissistigma polyanthum, which has traditionally been used as an important Chinese medicine, showed a certain free-radical-scavenging activity.
College of Pharmacy, South Central University for Nationalities, Wuhan 430074, P. R.
|How to cite this article:|
Fan H, Zheng T, Chen Y, Yang GZ. Chemical constituents with free-radical-scavenging activities from the stem of Fissistigma polyanthum.Phcog Mag 2012;8:98-102
|How to cite this URL:|
Fan H, Zheng T, Chen Y, Yang GZ. Chemical constituents with free-radical-scavenging activities from the stem of Fissistigma polyanthum. Phcog Mag [serial online] 2012 [cited 2020 Nov 25 ];8:98-102
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2012;volume=8;issue=30;spage=98;epage=102;aulast=Fan;type=0