Pharmacognosy Magazine

SHORT COMMUNICATION
Year
: 2011  |  Volume : 7  |  Issue : 26  |  Page : 171--175

Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants


Christine Chichioco-Hernandez1, Jakub Wudarski2, Lieven Gevaert2, Luc Verschaeve3 
1 Bioorganic and Natural Products Laboratory, Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines
2 Gentaur BVBA, Kampenhout, Belgium
3 Laboratory of Toxicology, O.D. Public Health and Surveillance, Scientific Institute of Public Health, Brussels, Belgium

Correspondence Address:
Christine Chichioco-Hernandez
Bioorganic and Natural Products Laboratory, Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City 1101
Philippines

The genotoxicity and toxicity of ethnomedicinal Philippine plants, which include Cassia fistula, Derris elliptica, Ficus elastica, Gliciridia sepium, Michelia alba, Morus alba, Pogostemon cablin and Ricinus communis, were tested using the Vitotox assay. The plants are used traditionally to treat several disorders like diabetes, weakness, menorrhagia, headache, toothache and rheumatism. The dried leaves were homogenized for overnight soaking in methanol at room temperature. The resulting alcoholic extracts were filtered and concentrated in vacuo and tested for their genotoxicity and cytotoxicity using Vitotox®. Results showed that the medicinal plants that were tested are not genotoxic nor cytotoxic, except for R. communis and P. cablin, which showed toxicity at high doses (low dilutions) in the absence of S9.


How to cite this article:
Chichioco-Hernandez C, Wudarski J, Gevaert L, Verschaeve L. Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants.Phcog Mag 2011;7:171-175


How to cite this URL:
Chichioco-Hernandez C, Wudarski J, Gevaert L, Verschaeve L. Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants. Phcog Mag [serial online] 2011 [cited 2021 Apr 18 ];7:171-175
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2011;volume=7;issue=26;spage=171;epage=175;aulast=Chichioco-Hernandez;type=0