Pharmacognosy Magazine

ORIGINAL ARTICLE
Year
: 2010  |  Volume : 6  |  Issue : 22  |  Page : 135--141

Protective effects of quercetin on liver injury induced by ethanol


Xi Chen 
 Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, 151 Malianwa North Road, Haidian District, Beijing 100193, China

Correspondence Address:
Xi Chen
Institute of Medicinal Plant Development, Beijing
China

Quercetin, a natural compound of multiple origins, has broad biopharmacological effects, such as antioxidant, directly scavenging free radical, and hepatoprotectivity effects. This study is designed to investigate the interveneous effect of quercetin on liver injury induced by ethanol in rats. The rats that were orally treated with 50% ethanol for continuous ten days, which resulted in cell necrosis, fibrosis and inflammatory infiltration, were included in this study. Higher contents of AST, ALT ADH, γ-GT, TG in plasma and MDA in liver tissue, and lower content of GSH in liver tissue were highlighted in ethanol-treated rats when compared with healthy ones. The levels of cytokines such as IL-1β, IL-1, IL-6, IL-8, and TNF-α in rats plasma were also significantly enhanced, and level of IL-10 was obviously lowered through ethanol treatment. By preventive and synchronism treatment with quercetin for fourteen days, the contents of AST, ALT ADH, γ-GT, TG and MDA, and levels of IL-1β, IL-1, IL-6, IL-8, and TNF-α were significantly reduced, whereas GSH and level of IL-10 were obviously increased. It may be deduced that quercetin, by multiple mechanisms interplay, demonstrated somewhat protective effect on liver injury induced by ethanol in rats.


How to cite this article:
Chen X. Protective effects of quercetin on liver injury induced by ethanol.Phcog Mag 2010;6:135-141


How to cite this URL:
Chen X. Protective effects of quercetin on liver injury induced by ethanol. Phcog Mag [serial online] 2010 [cited 2021 Jun 25 ];6:135-141
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2010;volume=6;issue=22;spage=135;epage=141;aulast=Chen;type=0