Pharmacognosy Magazine

RESEARCH ARTICLE
Year
: 2009  |  Volume : 5  |  Issue : 20  |  Page : 364--371

Therapeutic Effects of Allium sativum on Lead-induced Biochemical changes in Soft tissues of Swiss Albino Mice


Arti Sharma, Veena Sharma, Leena Kansal 
 Bioscience and Biotechnology Department, Banasthali University, Banasthali, India

Correspondence Address:
Arti Sharma
Bioscience and Biotechnology Department, Banasthali University, District Tonk, Banasthali-304022, Rajasthan
India

Allium sativum (Meaning pungent) belongs to the Alliaceae family and genus Allium, is generally known in the developing world for its characteristic flavor, a medicinal plant and a source of vegetable oil. Besides, the plant is reported to have various biological activities including hypocholesterolemic, antiatherosclerotic, anticoagulant, antibacterial, antifungal, anti-diabetic, anti­tumor agent; used for treating various disease such as inflammation, cardiovascular and liver diseases. The objective of this study is to investigate the therapeutic effects of Allium sativum on lead induced toxicity in mice. Chronic dose of lead (2 mg/Kg body weight, i.p.), showed significant decrease in antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and the nonenzymatic antioxidant as glutathione (GSH) and total protein content in the liver, kidney and brain. This decrease was accompanied with significant increase in lipid peroxidation and cholesterol level. Also, there were disturbances in the liver, kidney and brain functions manifested by significant changes in their functional markers. Efficacy of garlic to reduce tissue lead concentration was also evaluated. Mostly, all of the investigated parameters were restored nearly to the normal values after raw garlic extract treatment. In conclusion, garlic exerts its effects not only as an antioxidant but also as a sulfur donor. So, garlic has a promising role and it is worth to be considered as a natural chelating agent for lead intoxication.


How to cite this article:
Sharma A, Sharma V, Kansal L. Therapeutic Effects of Allium sativum on Lead-induced Biochemical changes in Soft tissues of Swiss Albino Mice.Phcog Mag 2009;5:364-371


How to cite this URL:
Sharma A, Sharma V, Kansal L. Therapeutic Effects of Allium sativum on Lead-induced Biochemical changes in Soft tissues of Swiss Albino Mice. Phcog Mag [serial online] 2009 [cited 2021 Jan 25 ];5:364-371
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2009;volume=5;issue=20;spage=364;epage=371;aulast=Sharma;type=0