Pharmacognosy Magazine

RESEARCH ARTICLE
Year
: 2009  |  Volume : 5  |  Issue : 19  |  Page : 93--99

Formulation and evaluation of topical polyherbal antiacne gels containing Garcinia mangostana and Aloe vera


Gowda Bhaskar, Shariff Arshia, S.R.B Priyadarshini 
 Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumarawsamy Layout, Bangalore-560078, India

Correspondence Address:
Gowda Bhaskar
Department of Pharmaceutics, Dayananda Sagar College of Pharmacy, Kumarawsamy Layout, Bangalore-560078
India

The objective of the study was to develop a topical poly herbal gel for the treatment of mild acne vulgaris. Aqueous extracts of Garcinia mangostana and Aloe vera were formulated in an aqueous based carbopol-934(1%w/w) gel system. Preformulation studies on solubility, partition co-efficient, MIC, MBC were determined along with compatibility studies using a validated HPLC method. Six formulations of the gel were prepared by varying the proportions of polymers and evaluated for their physicochemical properties like pH, spreadability, viscosity and microbial assay. Based on these tests, formulation F-6 containing 1% carbopol-934 was selected as best formulation and carried over to in-vitro drug diffusion studies wherein it showed Cumulative Drug Release of 81.03% at the end of 8 hours with a flux of 0.0879 mg/cm2/hr.The microbial assay of all the formulations demonstrated better inhibitory activity against Propionibacterium acne and Staphylococcus epidermidis compared to the marketed clindamycin phosphate gel in equivalent amounts of application. Conclusion: It was concluded from the study that aqueous extract of Garcinia mangostana and Aloe vera can be formulated in an aqueous based gel system for topical therapy of mild acne vulgaris.


How to cite this article:
Bhaskar G, Arshia S, Priyadarshini S. Formulation and evaluation of topical polyherbal antiacne gels containing Garcinia mangostana and Aloe vera.Phcog Mag 2009;5:93-99


How to cite this URL:
Bhaskar G, Arshia S, Priyadarshini S. Formulation and evaluation of topical polyherbal antiacne gels containing Garcinia mangostana and Aloe vera. Phcog Mag [serial online] 2009 [cited 2021 May 14 ];5:93-99
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2009;volume=5;issue=19;spage=93;epage=99;aulast=Bhaskar;type=0