Pharmacognosy Magazine

RESEARCH ARTICLE
Year
: 2009  |  Volume : 5  |  Issue : 19  |  Page : 100--104

Antiulcerogenic effects of Gymnosporia rothiana(Celastraceae) against different experimental models


AS Jain, SJ Surana 
 Department of Pharmacognosy, R.C.Patel College of Pharmacy, Karvand Naka, Shirpur-425405, Dist. Dhule, Maharashtra, India

Correspondence Address:
A S Jain
Department of Pharmacognosy, R.C.Patel College of Pharmacy, Karvand Naka, Shirpur-425405, Dist. Dhule, Maharashtra
India

Gymnosporia rothiana is used in Indian folk medicine as an antiulcerogenic agent. Despite of its promising use, there has been no scientific report present regarding its antiulcer activity. Therefore, this study was intended to evaluate the antiulcer property of various extracts of leaves of Gymnosporia rothiana at different dose levels in ethanol induced and indomethacin induced gastric ulcer models. It was observed that oral administration of all the extracts shows significant reduction in ulcer lesion index as well as increase in volume and pH of gastric content in both experimental models, being petroleum ether extract the most effective at dose of 250 mg/kg; it significantly reduced gastric lesion index (70.06%), in comparison to omeprazole (71.20%) and methanolic extract at a dose of 500 mg/kg (67.22%). Increased gastric mucosal defense mechanism by petroleum ether extract is probably due to its high levels of terpenoids like β amyrin, lupeol, friedelin. The present results clearly shows antiulcer effect of Gymnosporia rothiana against various irritants has been mainly due to cytoprotective effect mediated through prostaglandin and partly due to free radical scavenging activity.


How to cite this article:
Jain A S, Surana S J. Antiulcerogenic effects of Gymnosporia rothiana(Celastraceae) against different experimental models.Phcog Mag 2009;5:100-104


How to cite this URL:
Jain A S, Surana S J. Antiulcerogenic effects of Gymnosporia rothiana(Celastraceae) against different experimental models. Phcog Mag [serial online] 2009 [cited 2021 Oct 28 ];5:100-104
Available from: http://www.phcog.com/article.asp?issn=0973-1296;year=2009;volume=5;issue=19;spage=100;epage=104;aulast=Jain;type=0