Photoprotective and toxicological activities of extracts from the Antarctic moss Sanionia uncinata

Andréia da Silva Fernandes; Alexandre Santos Alencar; Heitor Evangelista; José Luiz Mazzei; Israel Felzenszwalb

Articles

Abstract

Pharmacognosy Magazine,2015,11,41,38-43.

DOI:10.4103/0973-1296.149701

Published:January 2015

Type:Original Article

Authors:

Author(s) affiliations:

Andréia da Silva Fernandes¹, Alexandre Santos Alencar¹, Heitor Evangelista¹, José Luiz Mazzei², Israel Felzenszwalb¹
¹ Department of Biophysics and Biometry, Institute of Biology Roberto Alcantara Gomes, Rio de Janeiro State University, Rio de Janeiro, Brazil
² Platform of Analytical Chemistry, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

Abstract:

Background: The Antarctic moss Sanionia uncinata (Hedw.) Loeske has shown high ultraviolet (UV)-absorbers content after exposition to high levels of UV-B radiation and can be an important source of antioxidants. Objective: The aim was to investigate photoprotection and mutagenicity by the aqueous extract (AE) and hydroethanolic extract (HE) from the Antarctic moss S. uncinata. Materials and Methods: Photoprotective activities were determined through survival curves of Escherichia coli strains, after UV irradiation in an aqueous solution of thymine and in vitro sun protection factor (SPF). The Salmonella/microsome assays were applied to assess the mutagenicity. Results: Both extracts induced photoprotection against UV-C radiation. The AE showed a higher protection than the hydroethanolic one against UV-induced thymine dimerization. The SPFs were low in both extracts. In association to benzophenone-3 a significant increase in the SPF was detected for the AE, and a significant decrease was induced by the HE. No mutagenicity was found in the both extracts. Furthermore, it was observed absence of cytotoxicity. Conclusion: Water-extractable compounds seem to contribute on photoprotection of this Antarctic moss.