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Year : 2022  |  Volume : 18  |  Issue : 78  |  Page : 450-457

Improvement effect of evodiae fructus water extract against DSS-induced ulcerative colitis

1 Department of Herbology, College of Korean Medicine, Daegu Haany University, 136, Shinchendong–ro, Suseong-gu, Deagu, 42158, Republic of Korea
2 College of Korean Medicine, Semyung University, 65, Semyung-Ro, Jecheon, Chungbuk 27136, Republic of Korea
3 DHU Bio Convergence Testing Center, 1, Hanuidae-ro, Gyeongsan-si, Gyeongsangbuk-do 38610, Republic of Korea
4 Department of Plant Science and Technology, Chung-Ang University, 4726, Seodong-daero, Daedeok-myeon, Anseong-si, Gyeonggi-do, 17546, Republic of Korea

Correspondence Address:
Seong-Soo Roh
Professor, Director, College of Korean Medicine, Daegu Haany University, 136, Shinchendong-ro, Suseong-gu, Deagu - 42158
Republic of Korea
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_465_21

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Background: Evodiae fructus is a natural plant that is used as a medicinal material in many Asian countries such as Korea and China. However, little is known about its effect on ulcerative colitis. Objectives: Thus, the purpose of this study was to find the improvement effect of Evodiae fructus in mice model with dextran sulfate sodium (DSS)-induced colitis. Materials and Methods: The animal experiments were conducted using ulcerative colitis animals induced by DSS. To induce ulcerative colitis in BALB/c mice used in the experiment, 5% DSS was supplied as drinking water for 7 days. BALB/c mice were divided into five groups (n = 8): Group 1 (normal group), Group 2 (5% DSS control group), Group 3 (5% DSS + sulfasalazine 60 mg/kg treated), Group 4 (5% DSS + Evodiae fructus water extract 50 mg/kg treated), Group 5 (5% DSS + Evodiae fructus water extract 100 mg/kg treated). After the animal experiment, the expression of antioxidant, oxidative stress, inflammatory, and necrosis-related factors in colonic tissues was analyzed by western blotting. Results: As a result, the Evodiae fructus treatment group reduced oxidative stress by increasing the expression of Nrf2, an antioxidant-related transcription factor. Also, the expression of NF-κB, an inflammatory transcription factor, was reduced, thereby reducing the expression of pro-inflammatory proteins and inflammatory cytokines. Conclusion: These results suggest that Evodiae fructus treatment has an inhibitory effect on inflammation against DSS-induced colitis. Therefore, Evodiae fructus has the potential to be used as a natural medicine for ulcerative colitis.

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