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Year : 2021  |  Volume : 17  |  Issue : 75  |  Page : 529-538

Antiresproative potency of D-carvone on ovariectomy-induced osteoporosis in rats

1 Department of Spinal Surgery, The People's Hospital of Dali Prefecture, Dali, Yunnan Province, China
2 Department of Pediatrics, College of Medicine, King Saud University, [Medical City], King Khalid University Hospital, Riyadh - 11461, Saudi Arabia
3 Department of Botany and Microbiology, College of Science, King Saud University, Riyadh -11451, Saudi Arabia
4 Department of Surgery, The Second People's Hospital of Dali County-level City, Dali, Yunnan Province, China

Correspondence Address:
Yanqiong Yang
Department of Surgery, The Second People's Hospital of Dali County-level City, Dali, Yunnan Province, 671000
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_449_20

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Background: Osteoporosis is a quiet disease with a pathological condition of reduced bone mineral density (BMD) leading to weakened bone. In this study, we evaluated the bone formation potency of D-carvone, an unsaturated monoterpenoid ketone phytochemical present in essential oil of aromatic plants with pharmacological prominence against the ovariectomy-induced rats. Materials and Methods: Ovariectomy was achieved in Sprague–Dawley rats and was employed for the present study. The rats were clustered into four sham-operated control, ovariectomized, ovariectomized treated with 5 mg/kg b. wt and 10 mg/kg b. wt, respectively. Body weight of rats was observed once a week and after the completion of treatment the rats were euthanized to isolate uterus, vagina, and femur. Results: The weight of the uterus, vagina, and femur were restrained to perceive the impact of D-carvone on reproductive organ and bone. The effect of D-carvone treatment in maintaining the BMD was evaluated with dual-energy X-ray absorptiometry scan and the biomechanical properties were measured with three-point bending test. Microcomputed tomography analysis was performed to scrutinize the D-carvone potency in trabecula of ovariectomized rats. Further to confirm D-carvone osteoblastic potency the bone turnover markers levels were enumerated. The bone healing effect of D-carvone in ovariectomized rats was considered with histological examination of femoral metaphysis. The impact of D-carvone on suppressing inflammation in ovariectomized rats was judged by estimating the levels of lipid profile and inflammatory cytokines. The osteoblastic potency of D-carvone was established by quantifying the gene expression osteblastic protein using quantitative polymerase chain reaction analysis. Conclusion: In conclusion, our results evidenced that the D-carvone effectively inhibited the osteclastic activity in ovariectomized rats and augmented the expression of osteblastic proteins via suppressing the inflammatory markers. However, the additional experiments in future could endorse the D-carvone as a potential anti-osteoporotic drug.

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