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Year : 2021  |  Volume : 17  |  Issue : 75  |  Page : 451-459

Deguelin treatment attenuated the lipopolysaccharides-provoked inflammation in murine macrophage and dextran sulfate sodium-inflamed acute colitis in mice through suppression of inflammatory markers

1 Department of Gastroenterology, Central Hospital of Haining, Haining, Zhejiang, 314408, China
2 Department of Spleen, Stomach and Gallbladder, Traditional Chinese Medical Hospital of Kunshan, Kunshan, Jiangsu, 215300, China
3 Chuxiong Medical College, Chuxiong, Yun'nan, 675000, China
4 Department of Anorectal, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003, China
5 Department of Botany and Microbiology, College of Science, King Saud University, Riyadh -11451, Saudi Arabia
6 Department of Pediatrics, College of Medicine, King Saud University, [Medical City], King Khalid University Hospital, Riyadh -11461, Saudi Arabia

Correspondence Address:
Lize Zhang
Department of Anorectal, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266003
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_570_19

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Background: Inflammatory bowel disease was a chronic inflammatory disease associated with the gastrointestinal region along with its two main types, i.e., ulcerative colitis and Crohn's disease. The occurrences of colitis were quickly expanding in recent decades worldwide. Objectives: In this investigation, we anticipated to examine the curative usefulness of deguelin, a natural herbal rotenoid against the lipopolysaccharide (LPS)-provoked inflammatory responses in murine macrophages and dextran sulfate sodium (DSS)-inflamed acute colitis in replica of mice. Materials and Methods: The inflammation response in RAW-264.7 cells was triggered with the LPS administration. The acute colitis was stimulated in BALB/c mice through administering the DSS. The colon length and disease activity index score was evaluated. The statuses of inflammatory arbitrators such as interleukin (IL)-6, tumor necrosis factor-α (TNF-α), and nitric oxide (NO) and enzymatic function of myeloperoxidase were inspected via commercial kits. The matrix metalloproteinase-2 expression in the colon tissues and colon histological examination were done to assess the deleterious effects of DSS in mice. Results: The deguelin treatment markedly alleviated the proinflammatory markers augmentation such as IL-6, TNF-α, and NO in the murine macrophages, as well as in DSS-provoked colitic mice. Deguelin markedly reversed the colon shortening and also improved the colon weight. The histopathological investigation of colon tissues exposed the protective effect of deguelin. A marked alleviation in DSS-incited colon inflammation was noted in the deguelin-supplemented mice. Conclusion: The findings of this research were established the remedial values of deguelin against the DSS-inflamed colitis in mice. It was clinched that the deguelin can be a promising therapeutic agent to treat the colitis.

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