Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2021  |  Volume : 17  |  Issue : 74  |  Page : 391-398

Antiarthritic activity of asiaticoside against the Freund's complete adjuvant-induced rheumatoid arthritis in experimental wistar rats

1 Department of Orthopedics, Qinghai Provincial People's Hospital, Xining, Qinghai, 810000, China
2 Department of International Ward (Orthopedics), Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610032, China
3 Orthopedic Center of the Fifth Affiliated Hospital of Xinjiang Medical University, Wulumuqi, Xinjiang, 830000, China
4 Department of Rehabilitation Medicine Kunming Municipal Hospital, Kunming, Yunnan, 650200, China
5 Six Wards, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Taizhou 318020, Zhejiang, Ch, China

Correspondence Address:
Jinwei Ying
Six Wards, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Taizhou 318020, Zhejiang
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_247_19

Rights and Permissions

Background: Rheumatoid synovial inflammation occurs at the synovial joint, which is activated by the articular system and mediated by the immune cells. In the case of untreated rheumatoid arthritis, the inflammation may affect the extra-articular system including cardiovascular, hepatic, respiratory, circulatory, and neuromuscular systems, which may ultimately interfere with the quality of life of patients with rheumatoid arthritis. This, in turn, reduces the life expectancy of the patient. Materials and Methods: The effectiveness of asiaticoside was evaluated by the Freund's complete adjuvant (FCA)-induced rheumatoid arthritis model using experimental Wistar rats. According to our results, asiaticoside exhibited potent anti-arthritic activity in contrast to the control animals in the FCA-induced rheumatoid arthritic model. Results: The parameters of arthritis such as reduced body weight, increased paw volume and pro-inflammatory cytokines, and cartilage destruction were significantly (P < 0.05) affected by the administration of asiaticoside. It significantly (P < 0.01) increased the body weight, decreased the paw volume and pro-inflammatory cytokines, restored the blood components, increased the levels of antioxidant enzymes, and protected the cartilage. Conclusion: Asiaticoside exhibited potential anti-arthritic activity against FCA-induced rheumatoid arthritis in experimental rats.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded152    
    Comments [Add]    

Recommend this journal