Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2021  |  Volume : 17  |  Issue : 74  |  Page : 275-281

Resveratrol exerts anti-inflammatory effect in lipopolysaccharide-induced lung inflammation via downregulation of antioxidant and inflammatory mediators


1 Department of Pulmonary and Critical Care Medcine, Chengdu Institute of Respiratory Health, The Third People's Hospital of Chengdu, Chengdu, Sichuan Province, China
2 Department of Intensive Medicine, The People's Hospital of Guangrao, Dongying, Shandong Province, China
3 Department of Emergency, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China
4 Department of ICU, Affiliated Hospital of Weifang Medical College, WeiFang, Shandong Province, China

Correspondence Address:
Xiaoming CHi
Department of ICU, Affiliated Hospital of Weifang Medical College, WeiFang, Shandong Province, 261031
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_41_20

Rights and Permissions

Background: Acute lung inflammation (ALI) is a serious health condition that causes severe pulmonary distress, tissue loss, and ultimately leads to death of the patient. Previously, theantagonisticrole of flavonoids has been extensively studied with respect to inflammation in cancer. Inflammatory reaction targeted during the lung cancer therapy. Aims and Objectives: In this study, the chemoprotective effect of resveratrol and its of mechanism of action against the Lipopolysaccharide (LPS)-induced lung inflammation was investigated. Materials and Methods: In this in vitro study, we performed experiments using RAW 264.7 cells. LPS was used to induce inflammation in the lungs of Swiss Wistar rats that were randomly divided into different groups. The rats were treated with resveratrol in a dose-dependent manner. The lung tissue and dry/wet weight of lung tissue was estimated. The antioxidant activity and anti-inflammatory parameters were also estimated. Results: According to results, resveratrol significantly reduced the secretion of pro-inflammatory cytokines including interleukin (IL)-1β, IL-4, IL-6, tumor necrosis factor-α (TNF-α), IL-18, IL-10, and antioxidant parameters viz., glutathione (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD), respectively. Resveratrol significantly (P<0.001) reduced the weight of lung tissue and dry/wet of lung tissue at dose-dependent manner. Conclusion: In summary, resveratrol plays the role of a chemo-protective agent against the LPS-induced lung inflammation via anti-inflammatory and antioxidant mechanism.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed268    
    Printed2    
    Emailed0    
    PDF Downloaded51    
    Comments [Add]    

Recommend this journal