Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2021  |  Volume : 17  |  Issue : 73  |  Page : 31-37

The inhibitory effects of different kinds of ginsenosides on skin pigmentation in melasma mice model


College of Chinese Medicine, Jilin Agricultural Science and Technology College, Jilin City, Jilin Province, China

Correspondence Address:
Shengxue Zhou
College of Chinese Medicine, Jilin Agricultural Science and Technology College, Jilin City 132101, Jilin Province
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_9_20

Rights and Permissions

Objectives: The study was aimed to compare the effects of seven different kinds of ginsenosides and total saponins on melasma and to explore their related mechanisms. Materials and Methods: The inhibitory rate of ginsenosides on tyrosinase (TYR) activity was measured in vitro. The skin cream comprising different kinds of ginsenosides was prepared and the melasma mice model was established. After successful modeling, different skin creams were applied to the backside of mice for 30 days and these mice were separated into 11 groups. Afterward, the melanocytes and melanin in the epidermal cells were analyzed under the microscope. Finally, the activity of superoxide dismutase (SOD), TYR and the content of malondialdehyde (MDA) in melasma mice were determined by different assay kits. Results: The outcomes of in vitro experiment showed that ginsenosides could affect TYR activity with different concentrations. In the melasma mice model, ginsenosides and total saponins inhibited the growth of melanocytes and the synthesis of melanin. Furthermore, with the increasing use of skin cream comprising ginsenosides and total saponins, the activity of SOD showed an increase trend, while MDA content and TYR activity exhibited a decrease trend. Thirty (30) days of treatment with ginsenosides (except for Rg1 and Rg2) and total saponins significantly increased the SOD activity and decreased the MDA and TYR levels compared with those in melasma mice without treatment (P < 0.05). Conclusion: Skin cream comprising ginsenosides Rb1, Rc, Rd, and Re could employ better protective roles in melasma by suppressing oxidative stress and inhibiting the synthesis of melanin.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1305    
    Printed28    
    Emailed0    
    PDF Downloaded258    
    Comments [Add]    

Recommend this journal