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ORIGINAL ARTICLE
Year : 2020  |  Volume : 16  |  Issue : 71  |  Page : 568-573

Synthesis, characterization, and biological activity of silver nanoparticles synthesized from Aristolochia bracteolata lam.


1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; Department of Pharmaceutics, Vidya Siri College of Pharmacy, Bengaluru, Karnataka, India
2 Department of Botany, Ramakrishna Mission Vivekananda College, Chennai, Tamil Nadu, India
3 Department of Biochemistry, Elayampalayam, Tiruchangode, Erode, Tamil Nadu, India
4 Deparment of Biotechnology, Vel's University, Chennai, Tamil Nadu, India
5 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia
6 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia; Department of Biotechnology and Food Technology, Durban University of Technology, Durban, South Africa
7 Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia
8 Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia
9 Department of Pharmacognosy, Vidya Siri College of Pharmacy, Bengaluru, Karnataka, India
10 Department of Pharmacognosy, Government College of Pharmacy, Bengaluru, Karnataka, India

Correspondence Address:
Nagaraja Sreeharsha
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_313_20

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The aim of this research is to analyze the antimicrobial activity and cytotoxicity of biologically synthesized silver nanoparticles against A549 cancer cell line. Silver nanoparticles were synthesized from the leaf extract of Aristolochia bracteolata. For the characterization of silver nanoparticles, Fourier transform infrared, high-performance liquid chromatography, and ultraviolet techniques were adopted. The silver nanoparticle was found to show better antimicrobial activity when compared to the crude extract of the plant. Noteworthy cytotoxic effects against A549 cell line were shown by the nanoparticles derived from the plant extract. Following the potential of biologically synthesized silver nanoparticles, they can be a valuable addition to the treatment of human laryngeal carcinoma and can be categorized as a potent anticancer agent.


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