| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 16
| Issue : 5 | Page : 566-572 |
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Protective effect of Viburnum grandiflorum against ultraviolet-B radiation-induced cellular and molecular changes in human epidermal keratinocytes
Hanjun Liu1, Haixiu Zhang2, Minyan Dang3, Yukiat Lin3, Hui Yan4
1 Department of Dermatology, Hanzhong People's Hospital, Hanzhong, Shaanxi 723000, China
2 Department of Dermatology, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan, Shandong 250012, China
3 Innoscience Research Sdn Bhd, Selangor, Malaysia
4 Department of Dermatology, The Second People's Hospital of Yunnan Province, Kunming, Yunnan 650021, China
Correspondence Address:
Hui Yan
Department of Dermatology, The Second Peoplefs Hospital of Yunnan Province, Kunming, Yunnan 650021
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/pm.pm_397_19
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The aim of the present study was to evaluate the photoprotective potential of Viburnum grandiflorum (VG) against ultraviolet-B radiation-induced responses in HaCaT cells. The HaCaT cells were pretreated with VG prior ultraviolet-B (UVB)-radiation exposure and were further examined for lipid peroxidation, enzymatic antioxidant activity, % reactive oxygen species, DNA damage, mitochondrial membrane potential and for inflammatory, and apoptotic signaling markers such as tumor necrosis factor-alpha, nuclear factor kappa B, interleukin-1 (IL-1), IL-6, cyclooxygenase-2, p53, caspase-3/9, cytochrome-c, Bax, and Bcl-2. The VG pretreatment in UVB exposed cells shows significantly regulated both inflammatory as well as apoptotic signaling cascades. Our findings suggest that VG may be functional against UVB-induced photo-damages.
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