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Year : 2019  |  Volume : 15  |  Issue : 66  |  Page : 386-395

Modulation of sodium arsenite-induced Toxicity in mice by ethanolic seed extract of Trigonella foenum graecum

1 Department of Zoology, Sidho-Kanho-Birsha University, Purulia, West Bengal, India
2 Department of Zoology, Midnapore College, Midnapore, West Bengal, India
3 Department of Zoology, Government Naveen College, Katekalyan, Dakshin Bastar, Dantewada, Chhattisgarh, India

Correspondence Address:
Surjyo Jyoti Biswas
Department of Zoology, Sidho-Kanho-Birsha University, Purulia (PO) Sainik School, Ranchi Road, Purulia - 723 104, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_518_18

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Background: Trigonella foenum graecum (TG) Linn. (Methi) is widely used as a spice and known for its pharmacological properties. Objective: The current study was conducted to examine the efficacy of TG Linn., family: Fabaceae, against sodium arsenite-induced toxicity in mice. Materials and Methods: Sixty mice (Mus musculus) weighing about 25 g were randomized into six groups; each of ten mice: Group I served as untreated control; Group II received only sodium arsenite (100 ppm) in drinking water for 2 months. The Group III mice fed chronically with sodium arsenite for 2 months as in Group II and then fed a vehicle of 1:20 alcohol to distilled water (1:20) for 15 and 30 days, respectively; Group IV to VI mice were treated as in Group II and then fed with 50, 150, and 250 mg/kg of TG seed extract, once daily for 15 and 30 days. Results: The IC50of the seed extract was 66.78 μg/mL, and it reduced the activities of toxicity marker enzymes such as gamma glutamyl transferase, lactate dehydrogenase, lipid peroxidation, aspartate transaminase, alanine aminotransaminase, acid phosphatase, alkaline phosphatase, and pro-inflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 (P < 0.05 to P < 0.001) and elevated the activities of catalase, superoxide dismutase, and G6PD (P < 0.05 to P < 0.001), a similar trend was also noted with hematological variables. Further, the normal architecture of the kidney was retained in the TG-fed series than arsenic (As)-treated series. Urinary excretion of As was high in treated groups compared to controls (P < 0.05 to P < 0.001), and 150 mg/kg dose offered better protection than the other two doses. Conclusion: TG seed extract has revealed potent antioxidant properties and consequently can be used as a protective agent in As-induced toxicity.

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