Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
Advanced search 
Year : 2019  |  Volume : 15  |  Issue : 65  |  Page : 722-729

Systematic estimation of potential risk caused by the replacement of aconite's cultivar

1 Agricultural College, Sichuan Agricultural University, Wenjiang, Chengdu, China
2 Tibet Vocational Technical College, Chengguan, Lhasa, Tibet, China
3 Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
4 College of Life Sciences, Sichuan University of Light Industry, Sichuan, China

Correspondence Address:
Mengliang Tian
Agricultural College, Sichuan Agricultural University, 211 Huimin Road, Wenjiang, Chengdu, Sichuan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/pm.pm_136_19

Rights and Permissions

Background: Aconite is a famous toxic medicinal plant in the world. But in China, the aconite cultivar, Qingchuan cultivar, which has been stably used for 2000 years, are being rapidly replaced by the Liangshan cultivar, a new cultivar with better agronomic traits. However, the risk of the replacement is still unknown. Materials and Methods: We combine field research and cultivation experiments to clarify differences in provenance and differences in agronomic traits. We used high-performance liquid chromatography (HPLC) to analyze the content of key ingredients in commercially available medicines and semi-finished drugs. We then performed a transcriptome analysis of the two resources to study the key differential pathways of the two species and conducted a systematic discussion. Statistical Analysis Used: Statistical differences were assessed by analysis of variance or least significant difference. P < 0.05 was considered statistically significant. Results: The survey and cultivation experiments showed that the overwhelming superiority of agronomic traits had already made Liangshan cultivar occupy the vast majority of areas. HPLC showed that the content of diester alkaloids in the Liangshan cultivar was slightly higher and that of higenamine was significantly lower. Analysis of the patented drug and fuzi flake demonstrated a strong correlation between higenamine and cardiac activity. Transcriptome analysis revealed that the upregulation of multiple genes in the isoquinoline pathway in Qingchuan cultivar resulted in the large difference of higenamine.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded222    
    Comments [Add]    

Recommend this journal