| ORIGINAL ARTICLE |
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| Year : 2019 | Volume
: 15
| Issue : 62 | Page : 1-4 |
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Androgen Receptor (NR3C4) regulator potential of Ceratonia siliqua extract and its signaling pathways
Fehmi Kigili1, Fatih Ozen2, Tunc Catal3, Belkıs Atasever Arslan1
1 Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul, Turkey
2 Department of Bioengineering, Uskudar University, Istanbul, Turkey
3 Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences; Istanbul Protein Research-Application and Innovation Center (PROMER), Uskudar University, Istanbul, Turkey
Correspondence Address:
Belkıs Atasever Arslan
Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Uskudar University, Istanbul 34662
Turkey
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/pm.pm_588_18
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Aim/Background: Androgen receptor (AR/NR3C4) regulates growth, development, reproduction, metabolism, and homeostasis. Since it has multifunctional properties, disrupting of the functions can cause many diseases such as cancer and neurodegenerative diseases. Therefore, AR modulators and blockers are very important therapy of androgen-dependent diseases. Furthermore, mechanisms and signaling pathways of AR on the diseases are unclear. Ceratonia siliqua was shown to have preventative effects against digestive system disorders, diabetes mellitus, asthma-bronchitis, and oxidative stress in various studies. Materials and Methods: In the present study, its AR regulator potential was investigated in AR-deficient HEK293 cells. Results: While C. siliqua extract increased >2 folds of NR3C4 gene expression in the cells, it induced a decrease in AKT1 and kynureninase genes expression levels. On the other hand, it increased p38 gene expression, but it did not change FUS gene expression. These results support a regulating role on the receptor and also that the compounds specifically affect NR3C4 signaling pathways. Conclusion: Determination of the molecules and their various combinations with each other can contribute to discover new therapeutic agents for diseases dependent on AR signaling pathways.
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