| ORIGINAL ARTICLE |
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| Year : 2019 | Volume
: 15
| Issue : 61 | Page : 219-225 |
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Dictamnus dasycarpus Turcz., root bark alleviates oxazolone-induced atopy-like dermatitis in mice
Beodeul Yang1, Ji Hyo Lyu1, Sura Kim1, Young Chul Park2, Koanhoi Kim3, Hyungwoo Kim1
1 Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam, South Korea
2 Department of Microbiology and Immunology, School of Medicine, Pusan National University, Yangsan, Gyeongnam, South Korea
3 Department of Pharmacology, School of Medicine, Pusan National University, Yangsan, Gyeongnam, South Korea
Correspondence Address:
Hyungwoo Kim
Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 50612
South Korea
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/pm.pm_110_18
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Background: Dictamnus dasycarpus Turcz., is one of the most frequently used herbal medicine to treat dermatosis associated with psoriasis, pruritus, scabies, and eczema. Objective: We investigated the anti-inflammatory effects of D. dasycarpus extract (DDE) using a mouse model with atopic dermatitis (AD)-like dermatitis. Materials and Methods: The therapeutic effects of DDE on skin lesion, tone of color, and inhibitory effects on histopathological changes and cytokine production in skin tissues were assessed in mice with AD-like dermatitis induced by oxazolone. Results: Topical application of DDE alleviated skin lesions such as erythema, scaling and excoriations, and ameliorated erythema and the melanin index. In addition, DDE effectively prevented skin enlargement induced by oxazolone, while also preventing epidermal hyperplasia, spongiotic change, and hyperkeratosis and reducing the production of tumor necrosis factor-alpha and interleukin (IL)-4 and IL-5 in inflamed tissues. Finally, DDE did not affect changes in body weight and spleen–body weight ratio relative to dexamethasone. Conclusion: These results indicate that D. dasycarpus can be used as a topical agent for inflammatory skin diseases with relative safety.
Abbreviation used: HM: Herbal medicine; DNFB: Dinitrofluorobenzene, ICAM-1: Intercellular adhesion molecule-1, AD: Atopic dermatitis, DDE: Dictamnus dasycarpus extract, AOO: Vehicle composed of acetone and olive oil, DEX: Dexamethasone, CBA: Cytometric bead array.
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