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ORIGINAL ARTICLE
Year : 2018  |  Volume : 14  |  Issue : 56  |  Page : 328-332

Immunostimulant activity of Bergenia Extracts


1 Department of Pharmacognosy, Faculty of Pharmacy Hradec Králové, Charles University, Sokolská, Hradec Králové, Czech Republic
2 Departmen of Clinical Immunology and Allergology, Faculty of Medicine and University Hospital, Charles University, Sokolská, Hradec Králové, Czech Republic

Correspondence Address:
Lenka Tumova
Department of Pharmacognosy, Faculty of Pharmacy Hradec Králové, Charles University, Heyrovského 500 05, Hradec Králové
Czech Republic
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_423_17

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Background: Bergenia species contain various therapeutically important compounds such as phenolic compounds-arbutin, bergenin, tannins, gallic acid, flavonoids, minerals, and many others. Bergenia plants show antibacterial, antiviral, anticancer, antidiabetic, diuretic and immunostimulant activities. Materials and Methods: Bergenia leaf extracts from Bergenia crassifolia, Bergenia ciliata, and Bergenia x ornata on lymphocyte activation using flow cytometry method were investigated. Their activation was then monitored with the help of the increasing fluorescence intensity. Results: By activating of cells, there has been an increase in the amount of the established antibodies. Bergenia extracts significantly stimulated the expression of CD69 on lymphocytes in the final concentration of 3.13 and 6.25 mg/ml. The values of stimulation indices of B. crassifolia and B. x ornata extract significantly statistically did not differ. Conclusion: The values of stimulation indices of B. crassifolia and B. x ornata extract significantly statistically did not differ.


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