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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 51  |  Page : 652-657

In vitro protoscolicidal effects of Cinnamomum zeylanicum essential oil and its toxicity in mice


1 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran
4 Department of Laboratory Sciences, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
5 Bam University of Medical Sciences, Bam; Research Center for Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran

Correspondence Address:
Mohammad Reza Aflatoonian
Bam University of Medical Sciences, Bam
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_280_16

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Background: This study investigates the scolicidal effects of Cinnamomum zeylanicum essential oil against the protoscoleces of hydatid cysts and its toxicity in the mice model. Materials and Methods: Gas chromatography/mass spectroscopy analyses were used to identify the constituents of essential oil. Protoscoleces were treated with different concentrations of the essential oil (6.25–100 μL/mL) in each test tube for 5–30 min. The viability of protoscoleces was confirmed using eosin exclusion test (0.1% eosin staining). Forty-eight male NMRI mice were also used to determine the toxicity of C. zeylanicum essential oil (0.5–4 mL/kg). Results: The main components were found to be cinnamaldehyde (91.8%), ρ metoxicinamate (1.57%), and α pinene (1.25%). Findings indicate that C. zeylanicum essential oil with the concentrations of 100 and 50 μL/mL killed 100% of protoscoleces after 5 min of exposure. Also, the lower concentrations of C. zeylanicum essential oil motivated a late protoscolicidal effect. The LD50value of intraperitoneal injection of C. zeylanicum essential oil was 2.07 mL/kg body weight after 48 h, and the maximum nonfatal dose was 1.52 mL/kg body weight. The results also showed that there was no significant toxicity following oral administration of C. zeylanicum essential oil for 2 weeks. Conclusion: The results exhibited the favorable scolicidal activity of C. zeylanicum, which could be applied as a natural scolicidal agent in hydatid cyst surgery.


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