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ORIGINAL ARTICLE
Year : 2017  |  Volume : 13  |  Issue : 51  |  Page : 452-457

Cytotoxic, antimitotic, and antiproliferation studies on Rasam: A South Indian traditional functional food


1 Department of Pharmaceutics, Hillside College of Pharmacy and Research Centre, Bengaluru, Karnataka; Department of Pharmacy, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India
2 Department of Pharmacy, Centre for Research and Development, PRIST University, Thanjavur, Tamil Nadu, India

Correspondence Address:
Agilandeswari Devarajan
Department of Pharmaceutics, Hillside College of Pharmacy and Research Centre, #9, Raguhuvanahalli, Kanakapura Main Road, Bengaluru - 560 062, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/pm.pm_138_17

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Background: Rasam is a traditional South Indian food, prepared using tamarind juice as a base, with a variety of spices. Rasam, with all its ingredients medicinally claimed for various ailments, is a functional food. Systematic consumption of traditional functional food provides an excellent preventive measure to ward off many diseases. Objective: To study rasam for cytotoxic, antimitotic, and antiproliferation potential beyond its culinary and nutritional effect. Materials and Methods: Brine shrimp lethality assay, onion root tip inhibition assay, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay in Calu-6, HeLa, MCF-7 cell lines for four stage-wise samples in the preparation of rasam (RS1, RS2, RS3, and RS4) were studied. Results: RS4, the end product of rasam showed high lethality with an LC50value of 38.7 μ L/mL. It showed maximum antimitotic activity in a dose-dependent manner compared to other samples with an IC50value of 189.86 μ L/mL. RS4 also showed an IC50value of 350.22 and 410.15 μ L/mL in MCF-7 and Calu-6 cell lines, respectively. Conclusion: From this study, we suggest that rasam is a classic example of traditional functional food and it can treat breast and lung cancer on chronic use. Abbreviations used: SS 316: Stainless Steel 316 grade; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; DMEM: Dulbecco's modified Eagle medium; FBS: Fetal bovine serum media; TPVG: Trypsin phosphate versene glucose; EDTA: Ethylene diamine tetra acetic acid; PBS: Phosphate buffered saline; DMSO: Dimethyl sulfoxide.


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