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Year : 2017  |  Volume : 13  |  Issue : 50  |  Page : 236-239

Evaluation of herb–drug interactions of Hovenia dulcis fruit extracts

1 Institute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Republic of Korea
2 Lifetree Biotech Co., Ltd., Suwon, Gyeonggi-do, Republic of Korea

Correspondence Address:
Prof. Hye Hyun Yoo
Institute of Pharmaceutical, Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do
Republic of Korea
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1296.204552

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Background: Hovenia dulcis (Rhamnaceae) fruits are popularly used as herbal medicines or dietary supplements in Asian countries due to functions such as liver protection and detoxification from alcohol poisoning. Accordingly, it is very likely for dietary supplemental products, including H. dulcis fruit extracts, to be taken with prescription drugs. Objective: In this study, possible food–drug interactions involving H. dulcis fruit extracts were evaluated based on the inhibition of cytochrome P450 (CYP) enzyme activity. Material and Methods: The water extract of H. dulcis fruit extracts was incubated in human liver microsomes with CYP-specific substrates. The formation of the CYP-specific metabolites was measured using liquid chromatography-tandem mass spectrometry. Results: H. dulcis fruit extracts showed negligible effects on seven CYP isozyme activities at all concentrations tested. Conclusion: This result suggests that H. dulcis fruit extracts may have minimal pharmacokinetic interactions with coadministered drugs through the modulation of CYP enzymes. Abbreviations Used: CYP: cytochrome P450 enzymes, HPLC: High performance liquid chromatography, LC-MS/MS : liquid chromatography-tandem mass spectrometry, MRM: multiple-reaction monitoring

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