| ORIGINAL ARTICLE |
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| Year : 2016 | Volume
: 12
| Issue : 46 | Page : 134-138 |
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A study on the chemical compositions of the Yinqiaosan (Lonicerae and Forsythiae powder) at different time of later-decoction by gas chromatography mass spectrometry
Yachun Shu1, Yajun Chen2, Kunming Qin3, Xiao Liu4, Baochang Cai4
1 Department of Pharmacy, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029; Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210046, China
2 Department of Pharmacy, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China
3 Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210046; Research and Development Center, Nanjing Haichang Chinese Medicine Group Corporation, Nanjing 210061, China
4 Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210046, China
Correspondence Address:
Baochang Cai
No. 12, Yongjin Road, Nanjing High-tech Industry Zone, Jiangsu 21006
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1296.177911
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Background: Yinqiaosan (Lonicerae and Forsythiae Powder), as a famous prescription of Dr. Wu Jutong in Qing dynasty of China, has the effects of diaphoresis cooling, fire-purging, and detoxicaton. It is mainly used in the treatment of influenza, hand-foot-mouth disease, esophagitis, pneumonia, acute tonsillitis, mumps, and other viral infections. It is one of the widely used traditional Chinese medicine prescriptions with proven curative effects in clinical use. Objective: To research the material basis of Yinqiaosan decoction when decocting mint, herba schizonepetae in different length of later-decoction time, to find the influence on volatile components of Yinqiaosan decoction decocted later in different length of time, to lay the foundation to further clarify the after-decoction mechanism of Yinqiaosan, and the specification of Yinqiaosan decoction process. Materials and Methods: Gas chromatography mass spectrometry method is used to analyze the volatile components of Yinqiaosan decoction samples decocted for 0, 3, 5, 8, and 10 min. Results: Later-decocting mint and herba schizonepetae at different time when decocting Yinqiaosan had a significant influence on the volatile components of the solution. 54 different chemical components were identified: 25 were identified when later-decocting the sample for 3 min; 13 were identified when later-decocting the sample for 5 min; 11 were identified when later-decocting the sample for 8 min; 7 were identified when later-decocting the sample for 10 min; and 26 were identified when later-decocting the sample for 0 min. There were more volatile components in the sample after-decocted for 3 min. A total of 54 different chemical components were identified in different later-decocting solution samples. These components form the basis of the Yinqiaosan drug effect. Conclusions: The length of later-decoction time of mint and herba schizonepetae was confirmed to be 3 min when decocting Yinqiaosan. |
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