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Year : 2016  |  Volume : 12  |  Issue : 45  |  Page : 31-35

Nuclear factor kappa B activation and peroxisome proliferator-activated receptor transactivational effects of chemical components of the roots of Polygonum multiflorum

1 College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
2 School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 712-749, Korea
3 Gyeongbuk Institute for Bio-industry, Andong City, Gyeongbuk 760-380, Korea
4 College of Pharmacy, Korea University, Sejong 339-700, Korea

Correspondence Address:
Young Ho Kim
College of Pharmacy, Chungnam National University, Daejeon 305-764
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1296.176019

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Background: Polygonum multiflorum is well-known as "Heshouwu" in traditional Chinese herbal medicine. In Northeast Asia, it is often used as a tonic to prevent premature aging of the kidney and liver, tendons, and bones and strengthening of the lower back and knees. Objective: To research the anti-inflammatory activities of components from P. multiflorum. Materials and Methods: The compounds were isolated by a combination of silica gel and YMC R-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-nuclear magnetic resonance, and mass spectrometry). The anti-inflammatory activities of the isolated compounds 1−15 were evaluated by luciferase reporter gene assays. Results: Fifteen compounds (1-15) were isolated from the roots of P. multiflorum. Compounds 1−5 and 14−15 significantly inhibited tumor necrosis factor-α-induced nuclear factor kappa B-luciferase activity, with IC 50 values of 24.16-37.56 μM. Compounds 1−5 also greatly enhanced peroxisome proliferator-activated receptors transcriptional activity with EC 50 values of 18.26−31.45 μM. Conclusion: The anthraquinone derivatives were the active components from the roots of P. multiflorum as an inhibitor on inflammation-related factors in human hepatoma cells. Therefore, we suggest that the roots of P. multiflorum can be used to treat natural inflammatory diseases.

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