Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 43  |  Page : 455-462

A study of pharmacokinetic interactions among co-existing ingredients in Viscum coloratum after intravenous administration of three different preparations to rats


Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

Correspondence Address:
Yunli Zhao
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016
China
Login to access the Email id

Source of Support: upported by the National Natural Science Foundation of China (Grant No. 30901967) and Natural Science Foundation of Liaoning Province (Grant No. 2013020223), Conflict of Interest: None declared.


DOI: 10.4103/0973-1296.160448

Rights and Permissions

Background: Viscum coloratum (Komar) Nakai, known as Hujisheng in china, has been widely used as a herb medicine to treat a variety of diseases, including cardiovascular diseases, cancer, hypertension, hepatitis and hemorrhage. Objective: The aim was to investigate pharmacokinetic interactions among co existing ingredients in V. coloratum after intravenous administration of three different preparations (four monomer solutions, the mixture of them and Viscum coloratum extracts) to rats. Materials and Methods: After protein precipitation pretreatment with plasma samples, high performance liquid chromatographic methods were developed and applied to quantitatively determinate the four components [syringin (Syri), homoeriodictyol 7 O-β-D glycoside (Hedt III), homoeriodictyol 7 O-β-D apiose (1 → 2)-β-D glycoside (Hedt II) and homoeriodictyol 7 O-β-D apiosiyl (1 → 5)-β-D apiosyl (1 → 2)-β-D glycoside (Hedt I)].The pharmacokinetic parameters (Area under the curve [AUC (0-t)], AUC (0-∞), t1/2) were calculated using DAS 2.1 software (Chinese Pharmacological Society,Shanghai,China) and compared statistically by One way analysis of variance using SPSS software (18.0, Chicago, IL, USA) with P < 0.05 considered statistically significant. Results: Good linearities were achieved in the measured concentration range with R2 it0.9920. Precision, accuracy and extraction recovery were all within the acceptable range. For Syri, there was a significant difference only on t1/2 among three treatment groups. For Hedt I, Hedt II and Hedt III, three flavonoid glycosides, the change of AUC (0-t), AUC (0-∞) and t1/2 were markedly distinctive and even converse. Conclusion: Complex, extensive pharmacokinetic interactions were observed among these components in V. coloratum. They were mutually influenced by the in vivo absorption, distribution, metabolism and elimination. The result suggested traditional Chinese medicine was a complicated system, and we should take a scientific and dialectic view in the research and development processes.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2306    
    Printed34    
    Emailed0    
    PDF Downloaded29    
    Comments [Add]    

Recommend this journal