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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 41  |  Page : 24-31

Hepatoprotective and antibacterial activity of Lippia nodiflora Linn. against lipopolysaccharides on HepG2 cells


1 Department of Pathology, Methodist Hospital Research Institute, Houston, Texas 77030, USA
2 Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA

Correspondence Address:
S Arumanayagam
Department of Pathology, Methodist Hospital Research Institute, Houston, Texas 77030
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.149689

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Background: Lippia nodiflora (LN) Linn is a small herb distributed throughout the world. The plant extracts of LN is used traditionally as an analgesic, anti-inflammatory, antioxidant, antibacterial, antimicrobial, antipyretic, antitumor, antidiabetic, and possess hepatoprotective properties. Materials and Methods: To study the antibacterial and hepatoprotective effect of LN, we used methanolic extracts of leaves on HepG2 cells. Lipopolysaccharides (LPS) is a well-characterized hepatotoxin, so toxicity was induced on liver cells using LPS. Up-regulation of inflammation genes were quantified. Results and Conclusions: In our present study, we have showed that LN reduced reactive oxygen species (ROS) production against LPS induced toxicity on HepG2 cells, and ther by decreased the apoptotic gene expression and protect the liver cells against toxicity.


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