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ORIGINAL ARTICLE
Year : 2015  |  Volume : 11  |  Issue : 41  |  Page : 117-122

Antihyperglycemic effects of Pandanus amaryllifolius Roxb. leaf extract


1 Department of Clinical Chemistry, Faculty of Allied Health Sciences, Center for Excellence in Omics Nano Medical Technology Development Project, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
2 Graduate Program in Clinical Biochemistry and Molecular Medicine, Faculty of Allied Health Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand

Correspondence Address:
Anchalee Chiabchalard
Department of Clinical Chemistry, Faculty of Allied Health Sciences, Center for Excellence in Omics Nano Medical Technology Development Project, Chulalongkorn University, Pathumwan, Bangkok 10330
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1296.149724

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Background: Diabetes mellitus is one of the leading chronic diseases worldwide. In patients with poor glycemic control, high blood glucose level may lead to other life-threatening complications. Pandanus amaryllifolius Roxb. (PA) leaves are used in traditional medicine for the treatment of diabetes. Objective: This study evaluated the effect of crude extract from PA leaves on blood glucose level and the hypoglycemic mechanisms. Materials and Methods: Thirty healthy volunteers were asked to drink PA tea (test-group) or hot water (control group) 15 min after glucose loading (75 g) in a standard oral glucose tolerance test. To study hypoglycemic mechanisms, PA leaves were extracted using two different methods. Method 1; dried PA leaves were extracted with distilled water at 90°C for 15 min, and method 2; dried PA leaves were extracted with 95% ethanol. Both PA extracts were tested for α-glucosidase enzyme inhibition, insulin stimulation, and glucose uptake stimulation. Results: The average of blood glucose level in the control group was 5.55 ± 0.98 mmol/l, while in PA treated group was 6.16 ± 0.79 mmol/l which were statistically different (P < 0.001). The results of antihyperglycemic mechanism showed that PA extracts, prepared both methods, could inhibit α-glucosidase enzyme and induce insulin production in rat pancreatic cell (RINm5F) in dose-dependent manner (P < 0.05). Conclusions: The knowledge gained from this research can be used as a basis for a new drug discovery for the treatment of diabetes.


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