| ORIGINAL ARTICLE |
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| Year : 2014 | Volume
: 10
| Issue : 38 | Page : 377-382 |
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Anti-inflammatory effects of Cryptotympana atrataFabricius slough shed on contact dermatitis induced by dinitrofluorobenzene in mice
Miyoung Kim1, Hanna Kim1, Jeonghyun Ryu1, Suzy Jo1, Guemsan Lee2, Mi Heon Ryu3, Hyungwoo Kim2, Su In Cho1
1 Division of Pharmacology, School of Korean Medicine, Pusan National University, Gyeongnam, South Korea
2 Department of Herbology, College of Korean Medicine, Wonkwang University, Jeonbuk, South Korea
3 Department of Oral Pathology, School of Dentistry, Pusan National University, Gyeongnam, South Korea
Correspondence Address:
Hyungwoo Kim
Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan City, Gyeongnam, 626-870
South Korea
 Source of Support: Basic Science Research Program through the National
Research Foundation of Korea (NRF) funded by the Ministry of Education,
Science and Technology (2012011676)., Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1296.133288
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Background: The slough shed of Cryptotympana atrata Fabricius is widely used to treat skin diseases in China, Japan, and Korea. Objective: To investigate the anti-inflammatory effects of C. atrata on contact dermatitis. Materials and Methods: We investigated the effects of C. atrata methanol extract (MECA) on ear swelling, histophathological changes and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis (CD) mice. Results: Topical application of MECA effectively inhibited enlargement of ear swelling (30 and 100 μ/ear, P < 0.05; 300 μg/ear, P < 0.01). MECA treatment also inhibited hyperplasia, spongiosis (100 and 300 μg/ear, P < 0.001), and immune cell infiltration (30 μg/ear, P < 0.05; 100 and 300 μg/ear, P < 0.001) induced by DNFB. In addition, treatment with MECA suppressed the increase in the levels of TNF-α (P < 0.05), IFN-g (3, 100 μg/ear, P < 0.05; 300 μg/ear, P < 0.01), and IL-6 (100 μg/ear, P < 0.05; 300 μg/ear, P < 0.01) production. Conclusion: These data suggest that MECA has the potential for use in the treatment of inflammatory skin diseases, including CD. Moreover, the results presented herein indicate that anti-inflammatory actions of MECA are mediated by decreasing production of TNF-α, IFN-γ, and IL-6 in inflamed tissues. |
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