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Year : 2014  |  Volume : 10  |  Issue : 37  |  Page : 80-85

Antiasthmatic effects of schizandrae fructus extract in mice with asthma

1 Associate Professor, School of Korean Medicine, Pusan National University, Pusan, South Korea
2 Department of Biomedical Science, Kyungdong University, Goseong-gun, Gangwon-do, South Korea
3 Master of Science, School of Korean Medicine, Pusan National University, Pusan, South Korea
4 Professor, School of Korean Medicine, Pusan National University, Pusan, South Korea

Correspondence Address:
Won Gun An
School of Korean Medicine, Pusan National University, Yangsan City, Gyeongnam - 626870
South Korea
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Source of Support: National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2012011676), Conflict of Interest: None

DOI: 10.4103/0973-1296.127348

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Background: Schizandrae fructus (SF), the fruit of Schisandra chinensis, has been used for the treatment of cough, wheezing, dry mouth, hepatitis, cardiovascular disease, and as a tonic and astringent in China, Japan, and Korea. Objective: Investigation of the antiasthmatic effects of SF. Materials and Methods: We investigated the effects of SF on airway hyperresponsiveness (AHR) to methacholine, production levels of antigen-specific antibodies, and histopathological changes in the lung tissue in a mouse model (Balb/c) of asthma induced by repeated intranasal instillation of an antigen. Results: SF lowered AHR to methacholine (P < 0.05), antigen-specific immunoglobulin E (IgE) level (P < 0.01), and immune cell infiltration in mice with asthma. Prednisolone (PD) effectively decreased AHR (P < 0.01), total antibody (P < 0.01) and IgE (P < 0.01) levels, and immune cell infiltration. SF and PD did not affect the levels of antigen-specific IgG1 and IgG2a antibodies. Conclusion: Our data suggest that SF has possible application as an antiasthmatic drug. We also suggest that SF could be used as a complementary or alternative medicine to glucocorticoids.

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