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Year : 2014  |  Volume : 10  |  Issue : 37  |  Page : 57-64

Optimization of quercitrin and total flavonoids extraction from Herba Polygoni Capitati by response surface methodology

1 The Research Center for Quality Control of Nature Medicine; Key Laboratory for Information System of Mountainous Area and Protection of Ecological Environment of Guizhou province, Guizhou Nomal University, Guiyang, Guizhou, China
2 Guizhou Warmen Pharmaceutical Co., Ltd., Guiyang, Guizhou, China

Correspondence Address:
Xin Zhou
The Research Center for Quality Control of Nature Medicine, Guizhou Normal University, Guiyang, Guizhou, 550 001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1296.127343

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Objective: To optimize the conditions for extraction of quercitrin and total flavonoids (TF) from Herba Polygoni Capitati (Touhualiao in Chinese) by using response surface methodology (RSM). Materials and Methods: A central composite design (CCD) was adopted to investigate the effects of three independent variables including solvent composition (%), solvent-material ratio (ml/g) and extraction time (min) on the responses, quercitrin and TF yields. Results: The optimized conditions of the extraction are as follows: Ethanol concentration, 65.63%; solvent-material ratio, 10.55:1 (ml/g); extraction time, 54.33 min. The established mathematical model described the factors of experimental parameters well and provided a statistically accurate prediction of the optimum yields of quercitrin and TF. Conclusion: The experimental values agreed with those predicted by the established mathematical model, thus indicating the suitability of the model employed and the success of RSM in optimizing the extraction conditions.

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