Home | About PM | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |  Login 
Pharmacognosy Magazine
Search Article 
Advanced search 

  Table of Contents  
Year : 2012  |  Volume : 8  |  Issue : 29  |  Page : 37-41  

Comparative study of rosmarinic acid content in some plants of Labiatae family

1 Department of Research and Development, Food and Drug Laboratory Research Center and Food and Drug Control Laboratories, MOH and ME, Tehran, Iran
2 Traditional Medicine and Materia Medica Research Center; Department of Traditional Pharmacy, Faculty of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Date of Submission26-Jan-2012
Date of Decision22-Feb-2011
Date of Web Publication28-Feb-2012

Correspondence Address:
Homa Hajimehdipoor
Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, Faculty of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran
Login to access the Email id

Source of Support: Tehran University of Medical Sciences and Health Services (Grant No. 87-04-56-7508), Conflict of Interest: None

DOI: 10.4103/0973-1296.93316

Rights and Permissions

Background: Plants of Labiatae are used in traditional medicine and phytotherapy. Rosmarinic acid (RA) is a phenolic compound which is found in many genus of Labiatae and exhibits important biological activities. Materials and Methods: In this investigation, RA contents of 29 species of Labiatae named Salvia officinalis, Salvia limbata, Salvia virgata, Salvia hypoleuca, Salvia macrosiphon, Salvia choloroleuca, Melissa officinalis, Origanum vulgare, Lavandula angustifolia, Rosmarinus officinalis, Thymus daenensis, Thymus citriodorous, Thymus pubescens, Thymus vulgaris, Zataria multiflora, Mentha piperita, Mentha pulegium, Mentha longifolia, Mentha spicata, Mentha aquatica, Mentha crispa, Perovskia artemisoides, Zhumeria majdae, Satureja hortensis, Satureja khuzistanica, Satureja bachtiarica, Satureja atropatana, Satureja mutica and Satureja macrantha were determined by using high-performance liquid chromatographic method. Results: The results showed that RA content in different species of Labiatae was 0.0-58.5 mg g -1 of dried plants. The highest amount of RA was found in Mentha species especially M. spicata. Conclusion: M. spicata can be considered as a new source of rosmarinic acid .

Keywords: High-performance liquid chromatographic, Labiatae, Mentha spicata, rosmarinic acid

How to cite this article:
Shekarchi M, Hajimehdipoor H, Saeidnia S, Gohari AR, Hamedani MP. Comparative study of rosmarinic acid content in some plants of Labiatae family. Phcog Mag 2012;8:37-41

How to cite this URL:
Shekarchi M, Hajimehdipoor H, Saeidnia S, Gohari AR, Hamedani MP. Comparative study of rosmarinic acid content in some plants of Labiatae family. Phcog Mag [serial online] 2012 [cited 2022 Aug 14];8:37-41. Available from: http://www.phcog.com/text.asp?2012/8/29/37/93316

   Introduction Top

Plants of Labiatae family have been used in traditional medicine for exhaustion, weakness, depression, memory enhancement, circulation improvement, strengthening of fragile blood vessels, [1] inflammation, infection, [2] indigestion and gastritis. [3] Researchers have proved that these plants are source of compounds with antioxidant, [4] anti-inflammatory, [5] anti-allergic, [6] anti-depression, [7] anti-hyperglycemic [8] and antimicrobial [9],[10],[11] properties. These activities are mostly related to their phenolic compounds content especially rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid [Figure 1] [1] which was isolated for the first time from Rosmarinus officinalis L. leaves and later found in other species of Labiatae and Boraginaceae. RA has interesting properties which has led to a broad range of applications from food preservatives to cosmetics. [12] Different studies have shown that antioxidant activity of RA is more than vitamine E [13] or Trolox. [14] RA has been reported to have some biological activities in vitro such as antiviral properties [15] including anti-HIV-1, [16] antibacterial, antioxidant, anti-carcinogenic, [17] and anti-allergic activities. [18] In vivo studies have shown that RA exhibit anti-allergic, [19],[20] anti-thrombotic, [21] and anti-carcinogenic [22],[23] properties as well. This compound is also efficient against peroxidative damage to biomembranes. [24] Nowadays, many products have been prepared from RA in pharmaceutical, cosmetic, and food industries. RA can be found in many plants but usually rosemary plant is used as the major source. This matter has caused to increase of demand and price of the plant. [25] Therefore, finding other plants containing high amount of RA is very important to introduce as new sources. This compound has been reported to occur in several taxonomically non-related families of the plant kingdom, but it is found abundantly in Labiatae. [26] In this investigation, in order to mark the best source of RA in Labiatae plants which grow in Iran, RA contents of 29 plants have been determined by using High-performance liquid chromatographic (HPLC) method. All of the plants are used as medicinal herbs or in food industries in different pats of Iran.
Figure 1: The structure of rosmarinic acid

Click here to view

   Materials and Methods Top

Plant material

Aerial parts of Salvia officinalis L., Salvia limbata C. A. Mey., Salvia virgata Jacq., Salvia hypoleuca Benth., Salvia macrosiphon Boiss., Salvia choloroleuca Rech. f. and Aell., Melissa officinalis L., Origanum vulgare L., Lavandula angustifolia Mill., Rosmarinus officinalis L., Thymus daenensis Celak, Thymus citriodorous (Pers.) Schreb., Thymus pubescens Boiss. and Kotschy ex Celak, Thymus vulgaris L., Zataria multiflora Boiss., Mentha piperita L., Mentha pulegium L., Mentha longifolia (L.) Huds., Mentha spicata L., Mentha aquatica L., Mentha crispa L., Perovskia artemisoides Boiss, Zhumeria majdae Rech., Satureja hortensis L., Satureja khuzistanica Jamzad, Satureja bachtiarica Bunge, Satureja atropatana Bunge, Satureja mutica Fisch. and C. A. Mey., and Satureja macrantha C. A. Mey., were collected from their growing area of Iran [Table 1] during flowering stage in summer 2008. Herbarium specimens were kept at the Herbarium of the Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences.
Table 1: Gradient time program for analysis of rosmarinic acid in Labiatae plants

Click here to view


Methanol (HPLC grade), 2-propanol (analytical grade), O-phosphoric acid (analytical grade) were purchased from Merck (Germany). The standard of rosmarinic acid was prepared from Aldrich (Germany). The water used in HPLC and for sample preparation was produced with a Purelab UHQ (ELGA) with a resistivity over 18 MΩ⋅cm.


A Waters high performance liquid chromatograph system comprising vacuum degasser, quaternary pump, auto sampler and a waters 2996 diode array detector was used. UV spectra were collected across the range of 200--900 nm extracting 330 nm for chromatograms. The column, an ACE 5 C 18 , (250 × 4.6 mm) was maintained at 30 °C. Mobile phase used for separation was the mixture of 0.085% O-phosphoric acid in water (A), 0.085% O-phosphoric acid in methanol (B), and 0.085% O-phosphoric acid in 2-propanol (C) in gradient mode [Table 1]. The flow rate, detection wavelength and sample injection volume were 1.0 ml min -1 , 330 nm, and 20 μl, respectively. [27] The chromatographic peak of rosmarinic acid was confirmed by comparing the retention time and UV spectra with that of related to the reference standard. Quantization was performed by using calibration curve of rosmarinic acid.

Preparation of standard solutions

Stock standard solution was prepared accurately by weighing 10 mg of rosmarinic acid reference standard into 10 ml volumetric flask and dissolving in water: methanol: 2-propanol (each one contained 0.085% O-phosphoric acid) (80:10:10) with the aid of ultrasonic. Serial dilutions (1-150 μg/ml) were made from stock solution.

Sample preparation

Milled and powdered samples (200 mg) were accurately weighed into a 25-ml tube, and extracted with 25 ml of the same solvent system for preparing standard solutions, during 30 min by ultrasonic. The resulting mixture was centrifuged at 4500 r/min for 5 min, and the supernatant transferred to a 100-ml volumetric flask. The residual solid was extracted for two more times with 25 ml of the same solvent mixture by ultrasonic, and centrifuged as above. The supernatants were combined, and diluted to 100 ml with the same solvent mixture. Each sample was extracted three times and injected (three times) to HPLC for analysis.

   Results and Discussion Top

Several mobile phases including methanol, water, acetonitrile, 2-propanol, THF and TFA in different combinations were tested. Finally, it was found that a 0.085% O-phosphoric acid in water: 0.085% O-phosphoric acid in methanol: 0.085% O-phosphoric acid in 2-propanol in gradient mode in 20 min [Table 1] gave the best separation. [27] After comparison between C 8 and C 18 columns, the best separation efficacy was obtained by using C 18 column. HPLC chromatogram of Mentha spicata sample and UV spectrum of RA in 11.16 min obtained from PDA detector have been shown in [Figure 2] and [Figure 3], respectively. Comparison between purity threshold and purity angle reported in em-power software showed that the method is specific for rosmarinic acid and reported peak is completely separated from other interfering compounds. The linear relationship between detector response and different concentrations of rosmarinic acid (eight levels) was confirmed in range of 1-150 μg/ml with correlation coefficient of 0.9983 and equation of y = 45337x-19410. In order to obtain the best recovery and peak shape of rosmarinic acid, different solvents and extraction methods were examined. Methanol, methanol followed by CCl 4 , methanol:water, methanol followed by hexane and water:methanol:2-propanol (each one contained 0.085% O-phosphoric acid) were used to investigate the effect of solvents on the RA extraction. Moreover, the effect of extraction time on the content of RA was studied (data was not shown). Finally, water:methanol:2-propanol (each one contained 0.085% O-phosphoric acid) (80:10:10) and ultrasonic for 30 min in three repeats were selected as the best parameters for RA extraction method.
Figure 2: High-performance liquid chromatographic Chromatograms of (a) Mentha spicata extract and (b) rosmarinic acid standard solution

Click here to view
Figure 3: UV spectrum of rosmarinic acid obtained from PDA detector at 11.16 min

Click here to view

The results showed that among analyzed plants belong to different genus of Labiatae family, the most RA contents were found in Mentha species. As it is observed in [Table 2], all Mentha species contain RA in considerable concentration (19.3--58.5 mg g -1 ) and M. spicata showed the highest amount of RA. Rosemary has been considered as a main source of RA in many countries [25] but the results demonstrated that the plant growing in Iran contains low RA concentration (7.2 mg g -1 ) compare to other investigated plants. Therefore, other plants such as Salvia officinalis, Melissa officinalis, Thymus citriodorous, Perovskia artemisoides and especially Mentha spicata which is widespread in Iran and very easy to access can be used as a source of RA in pharmaceutical, food and cosmetic industries. As it has been shown in [Table 2], no rosmarinic acid was detected in Thymus pubescens, Salvia choloroleuca and Zataria multiflora. Several investigations have been carried out in order to find new RA resources among plants. Achamlale et al., [25] showed that RA contents in Zostera noltii and Z. marina samples varied from 2.2 to 18.0 mg g -1 and 1.3--11.2 mg g -1 , respectively. They believed that the high RA content of these two sea-grasses is of interest for both cosmetic and herbal industries. Similar study has been performed on Melissa officinalis during different harvesting time. It has been shown that M. officinalis contained 39.1 mg g -1 of RA during full flowering stage [28] which is almost similar to RA content of M. officinalis from Iran (36.5 mg g -1 ). Another investigation on rosemary, sage, thyme, spearmint and lavender has proved that the plants contained 10.3, 10.4, 6.6, 10.7, and 2.0 mg g -1 of RA, respectively. [1] RA contents of rosemary and lavender obtained in our study were almost similar to the previous study. Therefore, rosemary can not be considered as RA source in all countries. Since, RA content of a plant is known to depend considerably on extrinsic and intrinsic factors including soil and climatic conditions, plant ontogenesis phases, harvest and plant storage, [29],[30],[31],[32] therefore, it is necessary to analyze the plants which are growing in each country for finding the best source of rosmarinic acid.
Table 2: Collection areas and concentration of rosmarinic acid in plants of Labiatae family

Click here to view

   Conclusion Top

RA is found in most of Labiatae plants growing in Iran and its concentration in some of species such as Salvia officinalis, Melissa officinalis, Thymus citriodorous, Perovskia artemisoides and Mentha spicata is considerable. These plants especially Mentha spicata can be used as RA resources in food, cosmetic and pharmaceutical industries instead of rosemary which contains low concentration of RA compare to other studied plants.

   Acknowledgments Top

This research has been supported by Tehran University of Medical Sciences and Health Services (Grant No. 87-04-56-7508).

   References Top

1.Wang H, Provan GJ, Helliwell K. Determination of rosmarinic acid and caffeic acid in aromatic herbs by HPLC. Food Chem 2004;87:307-11.  Back to cited text no. 1
2.Vieira A. A comparison of traditional anti-inflammation and anti-infection medicinal plants with current evidence from biomedical research: Results from a regional study. Pharmacogn Res 2010;2:293-5.  Back to cited text no. 2
3.Hajimehdipoor H, Shekarchi M, Khanavi M, Adib N, Amri M. A validated high performance liquid chromatography method for the analysis of thymol and carvacrol in Thymus vulgaris L. volatile oil. Pharmacogn Mag 2010;6:154-8.  Back to cited text no. 3
4.Zheng W, Wang SY. Antioxidant activity and phenolic compounds in selected herbs. J Agric Food Chem 2001;49:5165-70.  Back to cited text no. 4
5.Al-Sereiti MR, Abu-Amer KM, Sen P. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol 1999;37:124-30.  Back to cited text no. 5
6.Ito H, Miyazaki T, Ono M, Sakurai H. Antiallergic activities of Rabdosiin and its related compounds: Chemical and biochemical evaluations. Bioorg Med Chem 1998;6:1051-6.  Back to cited text no. 6
7.Takeda H, Tsuji M, Matsumiya T, Kubo M. Identification of rosmarinic acid as a novel antidepressive substance in the leaves of Perilla frutescens Britton var. acuta Kudo (Perillae Herba). Nihon Shinkei Seishin Yakurigaku Zasshi 2002;22:15-22.  Back to cited text no. 7
8.Kumar PM, Sasmal D, Mazumder PM. The antihyperglycemic effect of aerial parts of Salvia splendens (scarlet sage) in streptozotocin-induced diabetic-rat. Pharmacogn Res 2010;2:190-4.  Back to cited text no. 8
9.Nascimento EM, Rodrigues FF, Campos AR, Costa JG. Phytochemical prospection, toxicity and antimicrobial activity of Mentha arvensis (Labiatae) from northeast of Brazil. J Young Pharm 2009;1:210-2.  Back to cited text no. 9
10.Jain R, Kosta S, Tiwari A. Ayurveda and urinary tract infection. J Young Pharm 2010;2:337.  Back to cited text no. 10
11.Zomorodian K, Saharkhiz MJ, Rahimi MJ, Bandegi A, Shekarkhar G, Bandegani A, et al. Chemical composition and antimicrobial activities of the essential oils from three ecotypes of Zataria multiflora. Pharmacogn Mag 2011;7:53-9.  Back to cited text no. 11
12.Peterson M, Simmonds MS. Rosmarinic acid. Phytochemistry 2003;62:121-5.   Back to cited text no. 12
13.Lin YL, Chang Y, Kuo YH, Shiao MS. Anti-lipid-peroxidative principles from Tournefortia sarmentosa. J Nat Prod 2002;65:745-7.  Back to cited text no. 13
14.Lu Y, Foo LY. Polyphenolics of Salvia- A review. Phytochemistry 2002;75:197-202.  Back to cited text no. 14
15.Swarup V, Ghosh J, Ghosh S, Saxena A, Basu A. Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of Japanes encephalitis. Antimicrob Agents Chemother 2007;51:3367-70.  Back to cited text no. 15
16.Hooker CW, Lott WB, Harrich D. Inhibitors of human immunodeficiency virus type 1 reverse transcriptase target distinct phases of early reverse transcription. J Virol 2001;75:3095-104.  Back to cited text no. 16
17.Huang SS, Zheng RL. Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett 2006;239:271-80.  Back to cited text no. 17
18.Parnham MJ, Kesselring K. Rosmarinic acid. Drugs Future 1985;10:756-7.  Back to cited text no. 18
19.Makino T, Furuta A, Fujii H, Nakagawa T, Wakushima H, Saito K, et al. Effect of oral treatment of Perilla frutescens and its constituents on type-I allergy in mice. Biol Pharm Bull 2001;24:1206-9.  Back to cited text no. 19
20.Sanbongi C, Takano H, Osakabe N, Sasa N, Natsume M, Yanagizawa K, et al. Rosmarinic acid in Perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model. Clin Exp Allergy 2004;34:971-7.  Back to cited text no. 20
21.Zou ZW, Xu LN, Tian JY. Antithrombotic and antiplatelet effects of rosmarinic acid, a water-soluble component isolated from radix Salviae miltiorrhizae (danshen). Yao Xue Xue Bao 1993;28:241-5.  Back to cited text no. 21
22.Lee J, Kim YS, Park D. Rosmarinic acid induces melanogenesis through protein kinase A activation signalling. Biochem Pharmacol 2007;74:960-8.  Back to cited text no. 22
23.Osakabe N, Yasuda A, Natsume M, Yoshikawa T. Rosmarinic acid inhibits epidermal inflammatory responses: Anti-carcinogenetic effects of Perilla frutescens extract in the murine two-stage skin mode. Carcinogenesis 2004;25:549-57.  Back to cited text no. 23
24.Liu GT, Zhang TM, Wang BE, Wang YW. Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes. Biochem Pharmacol 1992;43:147-52.  Back to cited text no. 24
25.Achamlale S, Rezzonico B, Grignon-Dubois M. Rosmarinic acid from beach waste: Isolation and HPLC quantification in Zostera detritus from Arcachon lagoon. Food Chem 2009;113:878-83.  Back to cited text no. 25
26.Holzmannová V. Rosmarinic acid and its biological activity. Chem List 1996;90:486-96.  Back to cited text no. 26
27.Orhan I, Aslan S, Kartal M, Şener B, Başer KH. Inhibitory effects of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chem 2008;108:663-8.  Back to cited text no. 27
28.Tóth J, Mrlianová M, Tekeľová D, Koreòová M. Rosmarinic acid- an important phenolic active compound of lemon balm (Melissa officinalis L.). Acta Fac Pharm Univ Comenianae 2003;50:139-46.  Back to cited text no. 28
29.Adzet T, Ponz R, Wolf E, Schulte E. Genetic variability of essential oil content of Melissa officinalis. Planta Med 1992;58:558-61.  Back to cited text no. 29
30.Adzet T, Ponz R, Wolf E, Schulte E. Content and composition of Melissa officinalis oil in relation to leaf position and harvest time. Planta Med 1992;58:562-4.  Back to cited text no. 30
31.Hose S, Zänglein A, Van Den Berg T, Schultze W, Kubeczka KH, Czygan FC. Ontogenetic variation of the essential leaf oil of Melissa officinalis L. Pharmazie 1997;52:247-53.  Back to cited text no. 31
32.Mrlianová M, Tekeľová D, Felklová M, Reinöhl V, Tóth J. The influence of the harvest cut height on the quality of the herbal drugs Melissa folium and Melissa herba. Planta Med 2002;68:178-80.  Back to cited text no. 32


  [Figure 1], [Figure 2], [Figure 3]

  [Table 1], [Table 2]

This article has been cited by
1 Do we have infraspecific taxa of Salvia macrosiphon Boiss. (Lamiaceae) in Iran?
Seyed Mehdi Talebi, Mehri Askary, Maryam Samiei-Rad, Raheleh Tabaripour, Alex Matsyura
Molecular Biology Reports. 2022;
[Pubmed] | [DOI]
2 Antioxidant and antimicrobial chitosan films enriched with aqueous sage and rosemary extracts as food coating materials: Characterization of the films and detection of rosmarinic acid release
Nilay Kahya, Sacide Melek Kestir, Seray Öztürk, Alara Yolaç, Emrah Torlak, Zeynep Kalaycioglu, Gülsen Akin-Evingür, F. Bedia Erim
International Journal of Biological Macromolecules. 2022;
[Pubmed] | [DOI]
3 Sedative-hypnotic, anxiolytic and possible side effects of Salvia limbata C. A. Mey. Extracts and the effects of phenological stage and altitude on the rosmarinic acid content
Reza Jahani, Sahar Behzad, Maryam Saffariha, Niyusha Toufan Tabrizi, Mehrdad Faizi
Journal of Ethnopharmacology. 2022; 282: 114630
[Pubmed] | [DOI]
4 Evaluating chemical and thermal weed suppression in lemon balm (Melissa officinalis L.) cultivation
Andrzej Borowy, Magdalena Kaplan
Acta Scientiarum Polonorum Hortorum Cultus. 2022; 21(1): 39
[Pubmed] | [DOI]
5 Exploring the therapeutic potential of acetonic plant extracts in the healing of skin wounds infected with multidrug resistant pathogens
Maha A. Khalil, Eman H.F. Abd El-Zaher, Olaa Abd El-Salam, Sameh S. Ali
Journal of Applied Biomedicine. 2022;
[Pubmed] | [DOI]
6 Solubility of Rosmarinic Acid in Supercritical Carbon Dioxide Extraction from Orthosiphon stamineus Leaves
Ahmad Hazim Abdul Aziz, Nor Faadila Mohd Idrus, Nicky Rahmana Putra, Mohd Azrie Awang, Zuhaili Idham, Hasmadi Mamat, Mohd Azizi Che Yunus
ChemEngineering. 2022; 6(4): 59
[Pubmed] | [DOI]
7 In Vitro Strategy for the Enhancement of the Production of Bioactive Polyphenols in Transformed Roots of Salvia bulleyana
Marta Krzeminska, Aleksandra Owczarek, Monika A. Olszewska, Izabela Grzegorczyk-Karolak
International Journal of Molecular Sciences. 2022; 23(14): 7771
[Pubmed] | [DOI]
8 A Comprehensive Review of Rosmarinic Acid: From Phytochemistry to Pharmacology and Its New Insight
Huaquan Guan, Wenbin Luo, Beihua Bao, Yudan Cao, Fangfang Cheng, Sheng Yu, Qiaoling Fan, Li Zhang, Qinan Wu, Mingqiu Shan
Molecules. 2022; 27(10): 3292
[Pubmed] | [DOI]
9 Application of the Integrated Supercritical Fluid Extraction–Impregnation Process (SFE-SSI) for Development of Materials with Antiviral Properties
Ivana Lukic, Jelena Pajnik, Jakov Nisavic, Vanja Tadic, Erika Vági, Edit Szekely, Irena Zizovic
Processes. 2022; 10(4): 680
[Pubmed] | [DOI]
10 Oxidation during Fresh Plant Processing: A Race against Time
Didier Barmaverain, Samuel Hasler, Christoph Kalbermatten, Matthias Plath, Roger Kalbermatten
Processes. 2022; 10(7): 1335
[Pubmed] | [DOI]
11 Review on Lemon Balm Herb and its Evaluation
Rutuja R. Khatode, Pratiksha Deshmukh
International Journal of Advanced Research in Science, Communication and Technology. 2022; : 675
[Pubmed] | [DOI]
12 Methyl jasmonate enhances ursolic, oleanolic and rosmarinic acid production and sucrose induced biomass accumulation, in hairy roots of Lepechinia caulescens
Victor M. Vergara-Martínez, Samuel E. Estrada-Soto, Susana Valencia-Díaz, Karlina Garcia-Sosa, Luis Manuel Peña-Rodríguez, José de Jesús Arellano-García, Irene Perea-Arango
PeerJ. 2021; 9: e11279
[Pubmed] | [DOI]
13 Therapeutic Properties of Edible Mushrooms and Herbal Teas in Gut Microbiota Modulation
Emanuel Vamanu, Laura Dorina Dinu, Diana Roxana Pelinescu, Florentina Gatea
Microorganisms. 2021; 9(6): 1262
[Pubmed] | [DOI]
14 Seasonal Variations of Rosmarinic Acid and Its Glucoside and Expression of Genes Related to Their Biosynthesis in Two Medicinal and Aromatic Species of Salvia subg. Perovskia
Marta Stafiniak, Sylwester Slusarczyk, Bartosz Pencakowski, Adam Matkowski, Mehdi Rahimmalek, Monika Bielecka
Biology. 2021; 10(6): 458
[Pubmed] | [DOI]
15 Attacking COVID-19 Progression Using Multi-Drug Therapy for Synergetic Target Engagement
Mathew A. Coban, Juliet Morrison, Sushila Maharjan, David Hyram Hernandez Medina, Wanlu Li, Yu Shrike Zhang, William D. Freeman, Evette S. Radisky, Karine G. Le Roch, Carla M. Weisend, Hideki Ebihara, Thomas R. Caulfield
Biomolecules. 2021; 11(6): 787
[Pubmed] | [DOI]
16 Suppressive Effects of Rosmarinic Acid Rich Fraction from Perilla on Oxidative Stress, Inflammation and Metastasis Ability in A549 Cells Exposed to PM via C-Jun, P-65-Nf-?b and Akt Signaling Pathways
Komsak Pintha, Wittaya Chaiwangyen, Supachai Yodkeeree, Maitree Suttajit, Payungsak Tantipaiboonwong
Biomolecules. 2021; 11(8): 1090
[Pubmed] | [DOI]
17 Chemical Composition, Antioxidant Potential, and Blood Glucose Lowering Effect of Aqueous Extract and Essential Oil of Thymus Serrulatus Hochst. Ex Benth
Tesfay Haile, Susana M. Cardoso, Chirle de Oliveira Raphaelli, Olívia R. Pereira, Elisa dos Santos Pereira, Ma´rcia Vizzotto, Leonardo Nora, Adissu Alemayehu Asfaw, Gomathi Periasamy, Aman Karim
Frontiers in Pharmacology. 2021; 12
[Pubmed] | [DOI]
18 Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts
Kristina Bimbiraite-Surviliene, Mantas Stankevicius, Simona Šuštauskaite, Agnieszka Gegotek, Audrius Maruška, Elzbieta Skrzydlewska, Zita Barsteigiene, Ieva Akuneca, Ona Ragažinskiene, Audronis Lukošius
Antioxidants. 2021; 10(1): 53
[Pubmed] | [DOI]
19 The Antioxidant and Antimicrobial Capacities of Phenolic Profiles of Some Salvia L. Seeds Grown in Turkey
Irfan EMRE, Murat KURSAT, Sevda KIRBAG, Pinar ERECEVIT SÖNMEZ, Mustafa Yunus EMRE, Prof. Dr. Ökkes YILMAZ, Semsettin CIVELEK
International Journal of Secondary Metabolite. 2021; : 20
[Pubmed] | [DOI]
20 Protective effects of Lavandula stoechas L. methanol extract against 6-OHDA-induced apoptosis in PC12 cells
Zahra Tayarani-Najaran, Elham Hadipour, Seyed Mahdi Seyed Mousavi, Seyed Ahmad Emami, Leila Mohtashami, Behjat Javadi
Journal of Ethnopharmacology. 2021; 273: 114023
[Pubmed] | [DOI]
21 Measuring Plant Metabolite Abundance in Spearmint (Mentha spicata L.) with Raman Spectra to Determine Optimal Harvest Time
Jingzhe Li, Chamari S. Wijesooriya, Sadie J. Burkhow, Linda K. B. Brown, Beatrice Y. Collet, John A. Greaves, Emily A. Smith
ACS Food Science & Technology. 2021; 1(6): 1023
[Pubmed] | [DOI]
22 Phytochemical profile and rosmarinic acid purification from two Peruvian Lepechinia Willd. species (Salviinae, Mentheae, Lamiaceae)
Carlos A. Serrano, Gretty K. Villena, Eric F. Rodríguez
Scientific Reports. 2021; 11(1)
[Pubmed] | [DOI]
23 Mentha aquatica L. aerial parts: in vitro anti-proliferative evaluation on human tumour and non-tumour cell lines
Luciana Bitencourt de Souza, Sirlene Valerio Tinti, Ilza Maria de Oliveira Sousa, Ilio Montanari, José Luiz da Costa, João Ernesto de Carvalho, Mary Ann Foglio, Ana Lucia Tasca Gois Ruiz
Natural Product Research. 2021; : 1
[Pubmed] | [DOI]
24 Influences of freeze- and spray-drying vs. encapsulation with soy and whey proteins on gastrointestinal stability and antioxidant activity of Mediterranean aromatic herbs
Tea Bilušic, Ivana Drvenica, Ana Kaluševic, Zvonimir Marijanovic, Igor Jerkovic, Mario Nikola Mužek, Andre Bratanic, Danijela Skroza, Zoran Zoric, Sandra Pedisic, Viktor Nedovic, Anet Režek Jambrak
International Journal of Food Science & Technology. 2021; 56(4): 1582
[Pubmed] | [DOI]
25 Response of Mentha spicata L. to the reclamation of soil by the application of polyacrylamide (PAM): A soil-conditioner
Yawar Sadiq, Mohmmad Masroor Ahmad Khan, Asfia Shabbir, Bilal Ahmad, Hassan Jaleel, Ajmat Jahan
Journal of Food Processing and Preservation. 2021;
[Pubmed] | [DOI]
26 Synthesis, characterization and application of spherical and uniform molecularly imprinted polymeric nanobeads as efficient sorbent for selective extraction of rosmarinic acid from plant matrix
Sara Alipour, Parviz Aberoomand Azar, Syed Waqif Husain, Hamid Reza Rajabi
Journal of Materials Research and Technology. 2021; 12: 2298
[Pubmed] | [DOI]
27 Two-phase solvent extraction of phenolics from Origanum vulgare subsp. glandulosum
Schéhérazade Krim, Rachida Rihani, Luc Marchal, Alain Foucault, Fatiha Bentahar, Jack Legrand
Journal of Applied Research on Medicinal and Aromatic Plants. 2021; 20: 100273
[Pubmed] | [DOI]
28 Rosmarinic acid ameliorated cardiac dysfunction and mitochondrial injury in diabetic cardiomyopathy mice via activation of the SIRT1/PGC-1a pathway
Jiayu Diao, Hongmou Zhao, Penghua You, Hongjun You, Haoyu Wu, Xiling Shou, Gong Cheng
Biochemical and Biophysical Research Communications. 2021; 546: 29
[Pubmed] | [DOI]
29 Rosmarinic acid attenuates chromium-induced hepatic and renal oxidative damage and DNA damage in rats
Azem A. Khalaf, Eman I. Hassanen, Marwa A. Ibrahim, Adel F. Tohamy, Mahmoud A. Aboseada, Hossam M. Hassan, Amr R. Zaki
Journal of Biochemical and Molecular Toxicology. 2020; 34(11)
[Pubmed] | [DOI]
30 Conventional and nonconventional extraction techniques for optimal extraction processes of rosmarinic acid from six Lamiaceae plants as determined by HPLC-DAD measurement
Beatrix Sik, Erika Lakatos Hanczné, Viktória Kapcsándi, Zsolt Ajtony
Journal of Pharmaceutical and Biomedical Analysis. 2020; 184: 113173
[Pubmed] | [DOI]
31 Diversity of phytochemical components and biological activities in Zataria multiflora Boiss. (Lamiaceae) populations
Seyyed Hossein Pourhosseini, Mohammad Hossein Mirjalili, Masoud Ghasemi, Hamid Ahadi, Hassan Esmaeili, Mansour Ghorbanpour
South African Journal of Botany. 2020; 135: 148
[Pubmed] | [DOI]
32 Determination of Rosmarinic acid in plant extracts using a modified sensor based on magnetic imprinted polymeric nanostructures
Sara Alipour, Parviz Aberoomand Azar, Syed Waqif Husain, Hamid Reza Rajabi
Sensors and Actuators B: Chemical. 2020; 323: 128668
[Pubmed] | [DOI]
33 Ultraviolet-B-induced changes on phenolic compounds, antioxidant capacity and HPLC profile of in vitro-grown plant materials in Echium orientale L
Arzu Birinci Yildirim
Industrial Crops and Products. 2020; 153: 112584
[Pubmed] | [DOI]
34 Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing
Melanie-Jayne R. Howes, Nicolette S.L. Perry, Carlos Vásquez-Londoño, Elaine K. Perry
British Journal of Pharmacology. 2020; 177(6): 1294
[Pubmed] | [DOI]
35 Cytotoxic activity of Moroccan Melissa officinalis leaf extracts and HPLC-ESI-MS analysis of its phytoconstituents
Farid Khallouki, Andrea Breuer, Mourad Akdad, Fatima Ezzahra Laassri, Mohammed Attaleb, Benaissa Elmoualij, Mohammed Mzibri, Laila Benbacer, Robert W. Owen
Future Journal of Pharmaceutical Sciences. 2020; 6(1)
[Pubmed] | [DOI]
36 Quantification of chlorogenic acid, rosmarinic acid, and caffeic acid contents in selected Thai medicinal plants using RP-HPLC-DAD
Chayanon Chaowuttikul, Chanida Palanuvej, Nijsiri Ruangrungsi
Brazilian Journal of Pharmaceutical Sciences. 2020; 56
[Pubmed] | [DOI]
37 Phytochemical Characterization of Transilvanian Prunella vulgaris
Alexandra Grosan, Ruxandra ?tefanescu, Camil-Eugen Vari, George Jîtca, Madalina Batrânu, Lucia Daniela Muntean
Acta Biologica Marisiensis. 2020; 3(1): 62
[Pubmed] | [DOI]
38 Attenuation of Colonic Injury and Inflammation by Administration of a Phenolic Extract of Summer Savory (Satureja hortensis L.) in Experimental Inflammatory Bowel Disease in Mice
João Rocha, Raquel Leandro, Rosa Direito, Margarida Gonçalves, Maria Paula Duarte, Adelaide Fernandes, Bruno Sepodes, Maria-Eduardo Figueira
Applied Sciences. 2020; 10(23): 8465
[Pubmed] | [DOI]
39 The therapeutic effects of Agrimonia eupatoria L.
Z Paluch, L Biriczová, G Pallag, E Carvalheiro Marques, N Vargová, E Kmonícková
Physiological Research. 2020; : S555
[Pubmed] | [DOI]
40 Mitochondrial Dysfunction in Diabetic Cardiomyopathy: The Possible Therapeutic Roles of Phenolic Acids
Fatin Farhana Jubaidi, Satirah Zainalabidin, Vanitha Mariappan, Siti Balkis Budin
International Journal of Molecular Sciences. 2020; 21(17): 6043
[Pubmed] | [DOI]
41 HPLC profiling of selected phenolic acids and flavonoids in Salvia eigii, Salvia hierosolymitana and Salvia viridis growing wild in Jordan and their in vitro antioxidant activity
Hala I. Al-Jaber, Ashok K. Shakya, Zaha A. Elagbar
PeerJ. 2020; 8: e9769
[Pubmed] | [DOI]
42 Polyphenol Profile and Antimicrobial and Cytotoxic Activities of Natural Mentha × piperita and Mentha longifolia Populations in Northern Saudi Arabia
Hosam O. Elansary, Agnieszka Szopa, Pawel Kubica, Halina Ekiert, Marta Klimek-Szczykutowicz, Diaa O. El-Ansary, Eman A. Mahmoud
Processes. 2020; 8(4): 479
[Pubmed] | [DOI]
43 The Protective Effect of Rosmarinic Acid against Unfavorable Influence of Methylparaben and Propylparaben on Collagen in Human Skin Fibroblasts
Natalia Matwiejczuk, Anna Galicka, Ilona Zareba, Malgorzata M. Brzóska
Nutrients. 2020; 12(5): 1282
[Pubmed] | [DOI]
44 Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia
Kenjirou Ogawa, Ayumi Ishii, Aimi Shindo, Kunihiro Hongo, Tomohiro Mizobata, Tetsuya Sogon, Yasushi Kawata
Nutrients. 2020; 12(11): 3480
[Pubmed] | [DOI]
45 Variation in Fatty Acid Composition, Caffeic and Rosmarinic Acid Content, and Antioxidant Activity of Perilla Accessions
Da Jeong Kim, Awraris Derbie Assefa, Yi Jin Jeong, Young Ah Jeon, Jae Eun Lee, Myeong Chul Lee, Ho Sun Lee, Ju Hee Rhee, Jung Sook Sung
Korean Journal of Medicinal Crop Science. 2019; 27(2): 96
[Pubmed] | [DOI]
46 Analysis of Polyphenolic Composition of a Herbal Medicinal Product—Peppermint Tincture
Agnieszka Bodalska, Adam Kowalczyk, Maciej Wlodarczyk, Izabela Fecka
Molecules. 2019; 25(1): 69
[Pubmed] | [DOI]
47 Antibacterial Activity of Some Flavonoids and Organic Acids Widely Distributed in Plants
Artur Adamczak, Marcin Ozarowski, Tomasz M. Karpinski
Journal of Clinical Medicine. 2019; 9(1): 109
[Pubmed] | [DOI]
48 Features of Metabolomic Profiles in Different Stages of Ontogenesis in Prunella vulgaris (Lamiaceae) Grown in a Climate Chamber
N. V. Petrova, K. V. Sazanova, N. A. Medvedeva, A. L. Shavarda
Russian Journal of Bioorganic Chemistry. 2019; 45(7): 906
[Pubmed] | [DOI]
49 Metabolic interactions of rosmarinic acid with human cytochrome P450 monooxygenases and uridine diphosphate glucuronosyltransferases
Sang-Bum Kim, Kyu-Sang Kim, Dae-Duk Kim, In-Soo Yoon
Biomedicine & Pharmacotherapy. 2019; 110: 111
[Pubmed] | [DOI]
50 Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice
João Rocha, Rosa Direito, Ana Lima, Joana Mota, Margarida Gonçalves, Maria Paula Duarte, João Solas, Bruno Felício Peniche, Adelaide Fernandes, Rui Pinto, Ricardo Boavida Ferreira, Bruno Sepodes, Maria-Eduardo Figueira
Biomedicine & Pharmacotherapy. 2019; 118: 109351
[Pubmed] | [DOI]
51 Summer savory (Satureja hortensis L.) extract: Phytochemical profile and modulation of cisplatin-induced liver, renal and testicular toxicity
Tatjana Boroja, Jelena Katanic, Gvozden Rosic, Dragica Selakovic, Jovana Joksimovic, Danijela Mišic, Vesna Stankovic, Nemanja Jovicic, Vladimir Mihailovic
Food and Chemical Toxicology. 2018; 118: 252
[Pubmed] | [DOI]
52 An egg yolk’s phospholipid-pennyroyal nootropic nanoformulation modulates monoamino oxidase-A (MAO-A) activity in SH-SY5Y neuronal model
Rafael Vilamarim, João Bernardo, Romeu A. Videira, Patrícia Valentão, Francisco Veiga, Paula B. Andrade
Journal of Functional Foods. 2018; 46: 335
[Pubmed] | [DOI]
53 Grasslands: A Source of Secondary Metabolites for Livestock Health
Anne Poutaraud, Alice Michelot-Antalik, Sylvain Plantureux
Journal of Agricultural and Food Chemistry. 2017; 65(31): 6535
[Pubmed] | [DOI]
54 Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment
Doaa M. Hanafy,Paul D. Prenzler,Geoffrey E. Burrows,Danielle Ryan,Sharon Nielsen,Salma A. El Sawi,Taha S. El Alfy,Enas H. Abdelrahman,Hassan K. Obied
Journal of Functional Foods. 2017; 33: 345
[Pubmed] | [DOI]
55 Inhibitory effects of rosmarinic acid on pterygium epithelial cells through redox imbalance and induction of extrinsic and intrinsic apoptosis
Ya-Yu Chen,Chia-Fang Tsai,Ming-Chu Tsai,Yu-Wen Hsu,Fung-Jou Lu
Experimental Eye Research. 2017; 160: 96
[Pubmed] | [DOI]
56 Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity
Eva S.B. Lobbens,Karina J. Vissing,Lene Jorgensen,Marco van de Weert,Anna K. Jäger
Journal of Ethnopharmacology. 2017; 200: 66
[Pubmed] | [DOI]
57 A polyphenol complex from Thymus vulgaris L. plants cultivated in the Campania Region (Italy): New perspectives against neuroblastoma
Severina Pacifico,Simona Piccolella,Ferdinando Papale,Paola Nocera,Annamaria Lettieri,Michelina Catauro
Journal of Functional Foods. 2016; 20: 253
[Pubmed] | [DOI]
58 Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration
Juliana Maria de Mello Andrade,Carolina dos Santos Passos,Maria Angélica Kieling Rubio,Jacqueline Nakau Mendonça,Norberto Peporine Lopes,Amélia Teresinha Henriques
Chemico-Biological Interactions. 2016; 254: 135
[Pubmed] | [DOI]
59 Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects
Adrian L. Lopresti
Drugs in R&D. 2016;
[Pubmed] | [DOI]
60 Rosmarinic Acid suppressed high glucose-induced apoptosis in H9c2 cells by ameliorating the mitochondrial function and activating STAT3
Jiayu Diao,Jin Wei,Rui Yan,Xin Liu,Qing Li,Lin Lin,Yanhe Zhu,Hong Li
Biochemical and Biophysical Research Communications. 2016;
[Pubmed] | [DOI]
61 Rosmarinic acid is a homoserine lactone mimic produced by plants that activates a bacterial quorum-sensing regulator
A. Corral-Lugo,A. Daddaoua,A. Ortega,M. Espinosa-Urgel,T. Krell
Science Signaling. 2016; 9(409): ra1
[Pubmed] | [DOI]
62 Antiviral activity of Colombian Labiatae and Verbenaceae family essential oils and monoterpenes on Human Herpes viruses
Yaneth Miranda Brand,Vicky Constanza Roa-Linares,Liliana Amparo Betancur-Galvis,Diego Camilo Durán-García,Elena Stashenko
Journal of Essential Oil Research. 2016; 28(2): 130
[Pubmed] | [DOI]
63 A pharmacological and phytochemical overview onSatureja
Bektas Tepe,Mustafa Cilkiz
Pharmaceutical Biology. 2016; 54(3): 375
[Pubmed] | [DOI]
64 Phenolic and Volatile Composition of a Dry Spearmint (Mentha spicata L.) Extract
Martina Cirlini,Pedro Mena,Michele Tassotti,Kelli Herrlinger,Kristin Nieman,Chiara Dall’Asta,Daniele Del Rio
Molecules. 2016; 21(8): 1007
[Pubmed] | [DOI]
65 Organotypic Culture of Breast Tumor Explants as a Multicellular System for the Screening of Natural Compounds with Antineoplastic Potential
Irma Edith Carranza-Torres,Nancy Elena Guzmán-Delgado,Consuelo Coronado-Martínez,José Inocente Bañuelos-García,Ezequiel Viveros-Valdez,Javier Morán-Martínez,Pilar Carranza-Rosales
BioMed Research International. 2015; 2015: 1
[Pubmed] | [DOI]
66 Therapeutic and Nutraceutical Potential of Rosmarinic Acid - Cytoprotective Properties and Pharmacokinetic Profile
Sara Nunes,Raquel Madureira,Débora Campos,Bruno Sarmento,Ana Maria Gomes,Manuela Pintado,Flávio Reis
Critical Reviews in Food Science and Nutrition. 2015; : 00
[Pubmed] | [DOI]
67 Protective effect of rosmarinic acid against oxidative stress biomarkers in liver and kidney of strepotozotocin-induced diabetic rats
Nadia Mushtaq,Roberta Schmatz,Mushtaq Ahmed,Luciane Belmonte Pereira,Pauline da Costa,Karine Paula Reichert,Diéssica Dalenogare,Luana Paula Pelinson,Juliano Marchi Vieira,Naiara Stefanello,Lizielle Souza de Oliveira,Nadia Mulinacci,Maria Bellumori,Vera Maria Morsch,Maria Rosa Schetinger
Journal of Physiology and Biochemistry. 2015; 71(4): 743
[Pubmed] | [DOI]
68 Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation
Ji-Won Lee,Midori Asai,Sang-Kyung Jeon,Tadahiro Iimura,Takayuki Yonezawa,Byung-Yoon Cha,Je-Tae Woo,Akira Yamaguchi
Molecular Nutrition & Food Research. 2015; 59(3): 386
[Pubmed] | [DOI]
69 Establishment and characterization of a Satureja khuzistanica Jamzad (Lamiaceae) cell suspension culture: a new in vitro source of rosmarinic acid
Amir Sahraroo,Mohammad Hossein Mirjalili,Purificación Corchete,Mesbah Babalar,Mohammad Reza Fattahi Moghadam
Cytotechnology. 2015;
[Pubmed] | [DOI]
70 The safety of a dry spearmint extract in vitro and in vivo
Joanne A. Lasrado,Debbie Trinker,Michael A. Ceddia,Kelli A. Herrlinger
Regulatory Toxicology and Pharmacology. 2015; 71(2): 213
[Pubmed] | [DOI]
71 A critical overview on Thymus daenensis Celak.: phytochemical and pharmacological investigations
Mohammad M. Zarshenas,Liselotte Krenn
Journal of Integrative Medicine. 2015; 13(2): 91
[Pubmed] | [DOI]
72 Comparison of essential oil composition and phenolic acid content of selected Salvia species measured by GC–MS and HPLC methods
Bo Li,Chenlu Zhang,Liang Peng,Zongsuo Liang,Xijun Yan,Yonghong Zhu,Yan Liu
Industrial Crops and Products. 2015; 69: 329
[Pubmed] | [DOI]
73 A medicinal herb, Melissa officinalis L. ameliorates depressive-like behavior of rats in the forced swimming test via regulating the serotonergic neurotransmitter
Shih-Hang Lin,Mei-Ling Chou,Wei-Cheng Chen,Yi-Syuan Lai,Kuan-Hung Lu,Cherng-Wei Hao,Lee-Yan Sheen
Journal of Ethnopharmacology. 2015; 175: 266
[Pubmed] | [DOI]
74 1H NMR based metabolic profiling of eleven Algerian aromatic plants and evaluation of their antioxidant and cytotoxic properties
Nabila Brahmi,Monica Scognamiglio,Severina Pacifico,Aida Mekhoukhe,Khodir Madani,Antonio Fiorentino,Pietro Monaco
Food Research International. 2015; 76: 334
[Pubmed] | [DOI]
75 Differences in the chemotype of two native spearmint clonal lines selected for rosmarinic acid accumulation in comparison to commercially grown native spearmint
B. Narasimhamoorthy,L.Q. Zhao,X. Liu,W. Yang,J.A. Greaves
Industrial Crops and Products. 2014;
[Pubmed] | [DOI]
76 Bioactive Compounds from Culinary Herbs Inhibit a Molecular Target for Type 2 Diabetes Management, Dipeptidyl Peptidase IV
Allyson M. Bower,Luis M. Real Hernandez,Mark A. Berhow,Elvira Gonzalez de Mejia
Journal of Agricultural and Food Chemistry. 2014; 62(26): 6147
[Pubmed] | [DOI]
77 Improved Quality Control Method for Prescriptions of Polygonum capitatum through Simultaneous Determination of Nine Major Constituents by HPLC Coupled with Triple Quadruple Mass Spectrometry
Kai-Xia Zhang,Yue-Sheng Wang,Wen-Guang Jing,Jun Zhang,An Liu
Molecules. 2013; 18(10): 11824
[Pubmed] | [DOI]
78 Development and validation of HPLC coupled with triple quadrupole MS for the simultaneous determination of six phenolic acids, six flavonoids, and a lignan inPolygonum capitatum
Kaixia Zhang,Jun Zhang,Shenghua Wei,Wenguang Jing,Yuesheng Wang,An Liu
Journal of Separation Science. 2013; 36(15): 2407
[Pubmed] | [DOI]
79 development and validation of a method for the determination of rosmarinic acid in mentha piperita l. using solid-phase extraction and rp-hplc with photodiode array detection
gudzenko, a.
journal of chemical and pharmaceutical research. 2013; 5(9): 40-45
80 improved quality control method for prescriptions of polygonum capitatum through simultaneous determination of nine major constituents by hplc coupled with triple quadruple mass spectrometry
zhang, k.-x. and wang, y.-s. and jing, w.-g. and zhang, j. and liu, a.
molecules. 2013; 18(10): 11824-11835
81 Risk Factors of Recurrent Lumbar Disk Herniation
Mohammad Shimia,Arash Babaei-Gha,Bina Eftekhar Sadat,Behnaz Habibi,Afshin Habibzadeh
Pakistan Journal of Biological Sciences. 2013; 16(4): 180
[Pubmed] | [DOI]
82 Effects of Zataria Multi-Flora, Shirazi thyme, on the Severity of Premenstrual Syndrome
Marzieh Sodouri,Negin Masoudi Alavi,Nahid Fathizadeh,Mohsen Taghizadeh,Zohreh Azarbad,Mohammadreza Memarzadeh
Nursing and Midwifery Studies. 2013; 2(2): 57
[Pubmed] | [DOI]
83 Antioxidant and antibacterial properties of some fresh and dried Labiatae herbs
Eric Wei Chiang Chan,Lei Quan Kong,Kar Yen Yee,Wen Yee Chua,Tze Ying Loo
Free Radicals and Antioxidants. 2012; 2(3): 20
[Pubmed] | [DOI]
84 Development of a validated HPLC method for the simultaneous determination of flavonoids in Cuscuta chinensis Lam. by ultra-violet detection
Hajimehdipoor, H. and Kondori, B.M. and Amin, G.R. and Adib, N. and Rastegar, H. and Shekarchi, M.
DARU, Journal of Pharmaceutical Sciences. 2012; 20(1)
85 Protective effects of some medicinal plants from lamiaceae family against beta-amyloid induced toxicity in PC12 cell
Balali, P. and Soodi, M. and Saeidnia, S.
Tehran University Medical Journal. 2012; 70(7): 402-409
86 Assessment of role of rosmarinic acid in preventing oxidative process of low density lipoproteins
Andreia Tache,Gabriel-Lucian Radu,Simona-Carmen Litescu
Chemical Papers. 2012; 66(12): 1166
[Pubmed] | [DOI]
87 Development of a validated HPLC method for the simultaneous determination of flavonoids in Cuscuta chinensis Lam. by ultra-violet detection
Homa Hajimehdipoor,Babak kondori,Gholam Amin,Noushin Adib,Hossein Rastegar,Maryam Shekarchi
DARU Journal of Pharmaceutical Sciences. 2012; 20(1): 57
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Access Statistics
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this article
    Materials and Me...
    Results and Disc...
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded621    
    Comments [Add]    
    Cited by others 87    

Recommend this journal