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Year : 2011  |  Volume : 7  |  Issue : 25  |  Page : 14-18

The relaxant effect induced by Allium sativum L. bulb aqueous extract on rat isolated trachea

1 Department of Pharmacology and Toxicology, Tunisia Pharmaceutical Industries Company (SIPHAT), Fondouk Choucha-Radès, 2013 Ben Arous, Tunisia
2 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, P. O. Box 400, Al-Ahsa-31982, Kingdom of Saudi Arabia
3 Department of Biopharmaceutics, Faculty of Pharmacy, Auvergne University, 28, Place Henri Dunant - BP 38, 63001 Clermont-Ferrand, France

Correspondence Address:
Badreddine Fehri
B.P. 181, 2040 Radès
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1296.75879

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Background: Garlic plays an important role in complementary and alternative medicine. Most people believe in and use herbal products even when they have not been as thoroughly researched as garlic. Garlic is also known for its beneficial effects on the cardiovascular system. Materials and Methods: The relaxant effect of Allium sativum L. bulb aqueous extract (ASBAE) containing 0.06%-0.10% of allicin was studied on isolated smooth muscle of trachea of rats precontracted using acetylcholine (10−5 M). Results: It was found that ASBAE induced a dose-dependent relaxation with recorded EC 50 values of 71.87 ± 5.90 μg/mL (n = 7). Pretreatments with mepyramine (10−7 M), methysergide (10−7 M), caffeine (10−6 M), theophylline (10−6 M), nifedipine (10−6 M), and dipyridamole (10−6 M) did not alter ASBAE concentration-response curves. In turn, concentration-response curves to ASBAE were significantly shifted toward right in the presence of aspirin (3.10−3 M), indomethacin (10−6 M), prazosin (10−6 M), and propranolol (10−7 M). Conclusion: It is suggested that the recorded relaxation results are due to the release of prostaglandins E 1 and E 2 consecutively to a- and b-adrenoreceptor stimulation.

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