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| ORIGINAL ARTICLE |
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| Year : 2010 | Volume
: 6
| Issue : 22 | Page : 79-82 |
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Chemical composition and resistance-modifying effect of the essential oil of Lantana camara linn
Erlanio O Sousa1, Natalya F Silva1, Fabiola F.G Rodrigues1, Adriana R Campos2, Sidney G Lima3, Jose Galberto M Costa1
1 Programa de Pos-Graduacao em Bioprospeccao Molecular, Departamento de Química Biologica, Laboratorio de Pesquisa de Produtos Naturais, Universidade Regional do Cariri, Rua Cel. Antonio Luiz 1161, Pimenta, 63105-000, Crato-CE, Brazil
2 Vice-Reitoria de Pesquisa e Pos-Graduacao, Universidade de Fortaleza, Av. Washington Soares 1321, Edson Queiroz, 60811-905, Fortaleza-CE, Brazil
3 Departamento de Química, Universidade Federal do Piaui, Campus Universitário Ministro Petronio Portella, 64049-550, Bairro Ininga,Teresina-PI, Brazil
| Date of Submission | 09-Jan-2010 |
| Date of Decision | 03-Feb-2010 |
| Date of Web Publication | 30-Apr-2010 |
Correspondence Address:
Jose Galberto M Costa
Carolina Sucupira, 716 Crato, Ceara
Brazil
 Source of Support: Financial support from CAPES, CNPq and FUNCAP, and to UFPI for the chromatograms, Conflict of Interest: None  | Check |
DOI: 10.4103/0973-1296.62890
 Abstract | | |
In this work, the chemical constituents, antibacterial and modulatory activities of the essential oil of Lantana camara Linn were studied. The essential oil was extracted from the leaves of L. camara by hydrodistillation method using Clevenger's apparatus and its chemical constituents were separated and identified by GC-MS, and the relative content of each constituent was determined by area normalization. Among the 25 identified components, bicyclogermacrene (19.42%), isocaryophyllene (16.70%), valecene (12.94%) and germacrene D (12.34%) were the main constituents. The oil was examined to antibacterial and modulatory activities against the multiresistant strains of Escherichia coli and Staphylococcus aureus by microdilution test. The results show an inhibitory activity to E. coli (MIC 512 μg/ml) and S. aureus (MIC 256 μg/ml). The synergism of the essential oil and aminoglycosides was verified too, with significant reduction of MICs (7Χ, 1250-5 μg/ml) against E. coli. It is suggested that the essential oil of Lantana camara Linn could be used as a source of plant-derived natural products with resistance-modifying activity. Keywords: Lantana camara Linn, essential oil, aminoglycosides, antibacterial and modulatory activities
How to cite this article:
Sousa EO, Silva NF, Rodrigues FF, Campos AR, Lima SG, Costa JM. Chemical composition and resistance-modifying effect of the essential oil of Lantana camara linn. Phcog Mag 2010;6:79-82 |
How to cite this URL:
Sousa EO, Silva NF, Rodrigues FF, Campos AR, Lima SG, Costa JM. Chemical composition and resistance-modifying effect of the essential oil of Lantana camara linn. Phcog Mag [serial online] 2010 [cited 2022 Jul 1];6:79-82. Available from: http://www.phcog.com/text.asp?2010/6/22/79/62890 |
| Introduction | |  |
The emergence and spread of antimicrobial resistance justifies the high investment in the search of new drugs from vegetable species, in order to combat multiresistant microorganisms. [1],[2],[3],[4] Among the bacterial genera able to develop changes in their sensitivity to antimicrobials, Staphylococcus species have been recognized as having a worrying increase in antimicrobial resistance. [5],[6]
Despite causing different kinds of intoxications, S. aureus has been the most common etiological agent of festering infections that attack different tissues and/or organs (e.g. furuncle, carbuncle, abscess, myocarditis, endocarditis, pneumonia, meningitis, bacterial arthritis). [7],[8]
Escherichia More Details coli is a part of the intestinal microflora of most animals and humans and it is commonly associated with non complicated respiratory infections. Many reports have shown that E. coli has a tendency to be resistant to a range of antibiotics, mainly the β-lactamase producers.[9]
Five strains of E. coli, enterophatogenic E. coli (EPEC), enteroaggregative E. coli (EAEC), enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC) and Shiga toxin-producing E. coli (STEC), have been associated with human diseases. These E. coli categories are known to cause diarrhea and are responsible for diverse intestinal and extraintestinal diseases. [9]
Lantana is a genus of about 150 species of perennial flowering plants popularly used as antirheumatic, stimulant, antibacterial, biologic control and as ornamental plant. [10],[11]
Lantana camara Linn (camarα) is a shrub that belongs to Verbenaceae family. It is a native of America and Africa and has been cultivated as an ornamental plant in other countries. In Brazil, Lantana camara is found throughout al regions. [11],[12] Different parts of the plant, mainly the leaves, have been used in the treatment of scratching, stomachache, rheumatism, wound healing, biliary fever, toothache, bronquitis, antiseptic and other affections. [11],[13] In Brazil, the leaves are used to treat rheumatism and pulmonary diseases. [14]
The chemical study of essential oil of L. camara leaves revealed the presence of a high amount of sesquiterpenes and this oil remarkably inhibited the growth of most tested bacteria and fungi, Pseudomonas aeruginosa, Aspergillus niger, Fusarium solani and Candida albicans appearing as the most sensitive. [13]
The oil is reported to possess insecticidal and repellent activities toward bees, mosquitoes and cattle flies too. Dua et al.[10] showed that the essential oil of flowers has repellent effect against Aedes mosquitoes. This study was undertaken to screen the phytochemical composition and antimicrobial modulatory activity of Lantana camara Linn leaves essential oil from Cariri Cearense, Brazilian Northeast.
| Materials and Methods | | |
Plant material
Leaves of Lantana camara Linn were collected in March, 2009, from the Small Aromatic and Medicinal Plants Garden of the Natural Products Research Laboratory (LPPN) at University Regional do Cariri (URCA), Crato of county, Cearα state, Brazil.
A voucher specimen was sent to the Herbarium Caririense Dαrdano de Andrade Lima - HCDAL Department of Biological Sciences (URCA), which is deposited on the registration N° 1619.
Obtention of essential oil
Samples of fresh leaves (500 g) were triturated and submitted to hydrodistillation process, in a Clevenger-type apparatus for 2 h. The collected essential oil of Lantana camara (EOLc) was subsequently dried by anhydrous sodium sulfate (Na 2 SO 4 ), and stored under refrigeration at < 4 °C until be analyzed and tested.
Analysis of essential oil
Analysis by CG/MS of the essential oil was carried out on a Hewlett-Packard Model 5971 GC/MS using a non-polar DB-1 fused silica capillary column (30 m x 0.25 mm i.d., 0.25 μm film thickness); carrier gas helium, flow rate 0.8 ml/min and with split mode. The injector temperature and detector temperature were 250°C and 200°C, respectively. The column temperature was programmed from 35°C to 180°C at 4°C/min and then 180°C to 250°C at 10°C/min. Mass spectra were recorded from 30 to 450 m/z. Individual components were identified by matching their 70 eV mass spectra with those of the spectrometer data base using the Wiley L-built library and two other computer libraries MS searches using retention indices as a pre-selection routine, [15],[16] as well as by visual comparison of the fragmentation pattern with those reported in the literature. [17]
Investigation of antibacterial activity and minimal inhibitory concentration (MIC)
The antibacterial activity of the essential oil was investigated employing a microdilution method, recommended by NCCLS M7-A6. [18] In the assay, two multiresistant strains, Escherichia coli (27) from sputum and Staphylococcus aureus (358) from surgical wound, obtained from clinical material were used.
Brain hear infusion broth (BHI 3.8%) was used for bacterial growth (24 h, 35 ± 2°C). The inoculum was an overnight culture of each bacterial species in BHI broth diluted in the same media to a final concentration of approximately 1 x 10 8 CFU/ml (0.5 nephelometric turbidity units - McFarland scale). After this, the suspension was diluted to 1 x 10 6 CFU/ ml in 10% BHI. About 100 μl of each dilution was distributed in 96-well plates plus essential oils, achieving 5 x 10 5 CFU/ml as final concentration of the inoculum.
Essential oil was dissolved in distilled water and dimethyl sulfoxide (DMSO) to a concentration of 1024 μg/ml. Further serial dilutions were performed by the addition of BHI broth to reach a final concentration in the range of 8-512 μg/ml. All experiments were performed in triplicate and the microdilution trays were incubated at 35 ± 2°C for 24 h. Antibacterial activity was detected using a colorimetric method by adding 25 μl of resauzurin staining (0.01%) aqueous solution in each well at the end of the incubation period. The minimal inhibitory concentration (MIC) was defined as the lowest essential oil concentration able to inhibit the bacteria growth, as indicated by resauzurin staining (bacteria died cells are not able to change the staining color by visual observation - blue to red).
Modulatory activity evaluation
To evaluate the EOLc as a modulator of antibiotic resistance, the MICs of aminoglycosides (neomycin, canamycin, amikacin and gentamicin) against the analyzed strains were determined in the presence or absence of EOLm using the microdilution test. Subinhibitory concentrations (MIC 1/8) in 10% BHI were used.
The antibiotics solutions (5000 μg/ml) were prepared in distillated water for use the same day. A total of 100 μl of the antibiotic solution, using use serial dilutions (1:2), was added to the wells containing 10% BHI and the diluted bacterial suspension (1:10). Microplates were incubed for 24 h at room temperature and the antibacterial activity was determined as described before.
| Results and Discussion | | |
The essential oil obtained by hydrodistillation gave a yield of 0.12% (w/w). GC/MS analysis permitted the identification and quantification of twenty-five constituents (99.75%), with predominance of sesquiterpenes (56%) and a little amount of monoterpenes (44%) [Table 1]. These results are consistent with the previous reports that show a large percentage of sesquiterpenes in Lantana especies essential oils. [19],[20] Bicyclogermacrene (19.42%), isocaryophyllene (16.70%), valecene (12.94%) and germacrene D (12.34%) were the main constituents identified.
Caryophyllene isomers are the common constituents in Lantana species, and until now, germacrene D and bicyclogermacrene are components that appear in essential oils from Lantana species. It has been shown recently that the L. camara essential oil from the south of China is characterized by the high percentage of these sesquiterpenes. [21]
The EOLc antimicrobial properties against two bacteria strains by using microdilution assay for in vitro susceptibility testing were investigated. An inhibitory activity, clinically relevant, was verified against E. coli (MIC 512 μg/ml) and S. aureus (MIC 256 μg/ml), [Table 2]. These results are consistent with that of the previous studies by Deena and Thoppil [13] where they verified the antibacterial potential from L. camara against gram-positives strains default and mainly gram-negatives.
In an antibacterial screening using Lantana achyranthiofolia essential oil, an effective antibacterial activity against a multiresistant Staphylococcus epidermidis  strain and Vibrio cholerae strains was verified.[22] This result indicates the strong antimicrobial potential of the Lantana species essential oil against multiresistant bacteria strains.
[Table 3] shows the EOLc inteference on aminoglycosides activities (MIC 1/8). MICs reduction for all antibiotics used here was observed when EOLc was added to the growth medium. The most expressive effect was the potentiation of amikacin on E. coli by EOLc, with seven-fold MIC reduction (1250-5 μg/ml).
According to Oliveira et al., [23] the essential oil antimicrobial modifying effect is dependent on the antibiotic, essential oil tested and analyzed bacteria strain types.
Few works report the antibiotic potentializing effect by essential oils when in combination with classical antibiotics. Individual compounds of essential oils from Melaleuca leucodendron and Ocimum gratissimum presented synergism with several antibiotics by direct contact. [24] As far as we know, there is no report about the potentiation of aminoglycoside effects by L. camara or other Lantana specie.
Several reports indicate different antibiotic combinations assayed in vitro and applied in the clinics, but combinations of natural products and synthetic drugs are not reported. The results showed here are indicative that L. camara can play a role as a source of natural products acting as an antibiotic resistance modifier that can be used against multiresistant bacteria.
| Acknowledgments | | |
The authors would like to acknowledge the financial support from CAPES, CNPq and FUNCAP, and to UFPI for the chromatograms.
| References | | |
| 1. | Oliveira FQ, Gobira B, Guimarγes C, Batista J, Barreto M, Souza M. Espιcies vegetais indicadas na odontologia. Rev Bras Farmacogn 2007;17:466-76.  |
| 2. | Costa JGM, Rodrigues FFG, Angιlico EC, Pereira CK, Sousa EO, Caldas GF. Composiηγo quνmica e avaliaηγo da atividade antibacteriana e toxicidade do σleo essencial de Croton zehntneri (variedade estragol). Rev Bras Farmacogn 2007;18:583-6. |
| 3. | Silva JG, Souza IA, Higino JS, Siqueira-Junior JP, Pereira JV, Pereira MS. Atividade antimicrobiana do extrato de Anacardium occidentale Linn em amostras multiresistentes de Staphylococcus aureus. Rev Bras Farmacogn 2007;17:572-7. |
| 4. | Coutinho HDM, Costa JGM, Siqueira-Jϊnior JP, Lima EO. In vitro anti-staphylococcal activity of Hyptis martiusii Benth against methicillin-resistant Staphylococcus aureus-MRSA strains. Rev Bras Farmacogn 2008;8:670-5. |
| 5. | Georgopapadakou NH. Infectious disease 2001: drug resistance, new drugs. Drug Resist Updat 2002;5:181-91. |
| 6. | Nostro A, Blanco AR, Cannatelli MA, Enea V, Flamini G, Morelli I, et al. Susceptibility of methicillin-resistant staphylococci to oregano essential oil, carvacrol and thymol. FEMS Microbiol Lett 2004;230:191-5. |
| 7. | Verhoef J, Beaujean D, Blok H, Baars A, Meyler A, van der Werken C, et al. A dutch approach to methicillin-resistance Staphylococcus aureus. Eur J Clin Microbiol Infect Dis 1999;18:461-6. |
| 8. | Pereira MS, Siqueira-Jϊnior JP, Takaki GM. Elimination of resistance to drugs by fluoroquinolones in bovine strains of Staphylococcus aureus. Pesq Vet Bras 2004;24;11-4. |
| 9. | Paula CJS, Marin JM. Isolation of extraintestinal pathogenic Escherichia coli from diarrheic dogs and their antimicrobial resistance profile. Braz J Microbiol 2008;39:498-500. |
| 10. | Dua VK, Gupta NC, Pandey AC, Sharma VP. Repellency of Lantana camara (Verbenaceae) flowers against Aedes mosquitoes. J Am Mosq Control Assoc 1996;12:406-8. |
| 11. | Ghisalberti EL. Lantana camara L. (Verbenaceae). Fitoterapia 2000;71:467-86. |
| 12. | Brito MF, Tokarnia CH, Dφbereiner I. A toxidez de diversas lantanas para bovinos e ovinos no Brasil. Pesq Vet Bras 2004;24:153-9. |
| 13. | Deena MJ, Thoppil JE. Antimicrobial activity of the essential oil of Lantana. Fitoterapia 2000;71:453-5. |
| 14. | Lorenzi H, Matos FJ. Plantas Medicinais no Brasil: Nativas e Exσticas Cultivadas. Computaηγo grαfica Osmar Gomes. Nova Odessa, SP: Instituto Plantarum; 2002. |
| 15. | Alencar JW, Craveiro AA, Matos FJ. Kovat's indices as a preselection routine in mass spectra library search of volatiles. J Nat Prod 1984;47:890-2. |
| 16. | Alencar JW, Craveiro AA, Matos FJ, Machado MI. Kovats indices simulation in essential oils analysis. Quim Nova 1990;13:282-4. |
| 17. | Adams RP. Identification of Essential Oil Components by Gas Chromatography/Quadrupole Mass Spectroscopy; Allured Publishing Corporation. Allured Publishing Corporation. Illinois, USA: Carol Stream; 2001. |
| 18. | National Committee for Clinical Laboratory Standards; Methods for Dilution Antimicrobial Susceptibility Tests for bacteria that grow aerobically, Approved Standard M7-A6, NCCLS: Wayne; 2003; 23. |
| 19. | Ngassoum MB, Yonkeu S, Jirovetz L, Buchbauer G, Schmaus G, Hammerschmidt FJ. Chemical composition of essential oils of Lantana camara leaves and flowers from Cameroon and Madagascar. Flav Fragr J 1999;14:245-50. |
| 20. | Silva MH, Andrade EH, Zoghbi MG, Luz AI, Silva JD, Maia JG. Essential Oils of Lantana camara L. Occurring at North Brazil. Flav Fragr J 1999;14:208-10. |
| 21. | Sundufu AJ, Shoushan H. Chemical composition of the essential oils of Lantana camara L. occurring in south China. Flav Fragr J 2003;19:229-32. |
| 22. | Hernαndez T, Canales M, Avila JG, Garcνa AM, Martνnez A, Caballero J, Vivar AR, Lira Rl. Composition and antibacterial activity of essential oil of Lantana achyranthifolia Desf. (Verbenaceae). J Ethnopharmacol 2005;96:551-4. |
| 23. | Oliveira RA, Lima EO, Vieira WL, Freire KR, Trajano VN, Lima IO, Souza EL, Toledo MS, Silva-Filho RN. Estudo da interferκncia de σleos essenciais sobre a atividade de alguns antibiσticos usados na clνnica. Rev Bras Farmacogn 2006;16:77-82. |
| 24. | Rodrigues FFG, Costa JGM, Coutinho HDM. Synergy effects of the antibiotics gentamicin and the essential oil of Croton zehntneri. Phytomedicine 2008;16:1052-5. |
[Table 1], [Table 2], [Table 3]
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|
| Soon-Nang Park,Yun Kyong Lim,Marcelo Oliveira Freire,Eugene Cho,Dongchun Jin,Joong-Ki Kook | | Anaerobe. 2012; 18(3): 369 | | [Pubmed] | [DOI] | | | 30 |
Chemical composition and antibacterial properties of the essential oil and extracts of Lantana camara Linn. from Uttarakhand (India) |
|
| Richa Seth,Manindra Mohan,Prashant Singh,Syed Zafar Haider,Sanjay Gupta,Irshita Bajpai,Deepak Singh,Rajendra Dobhal | | Asian Pacific Journal of Tropical Biomedicine. 2012; 2(3): S1407 | | [Pubmed] | [DOI] | | | 31 |
Types of endophytic bacteria associated with traditional medicinal plant Lantana camara Linn. |
|
| Bhore Subhash Janardhan,Komathi Vijayan | | Pharmacognosy Journal. 2012; 4(32): 20 | | [Pubmed] | [DOI] | | | 32 |
Antimicrobial Effect of Carvacrol against Cariogenic and Periodontopathic Bacteria |
|
| Soon-Nang Park,Dong-Kyun Lee,Yun-Kyong Lim,Hwa-Sook Kim,Eu-Gene Cho,Dongchun Jin,Saeng-Gon Kim,Joong-Ki Kook | | The Korean Journal of Microbiology. 2012; 48(1): 52 | | [Pubmed] | [DOI] | | | 33 |
A weed with multiple utility: Lantana camara |
|
| Seema Patel | | Reviews in Environmental Science and Bio/Technology. 2011; 10(4): 341 | | [Pubmed] | [DOI] | | | 34 |
A weed with multiple utility: Lantana camara |
|
| Patel, S. | | Reviews in Environmental Science and Biotechnology. 2011; 10(4): 341-351 | | [Pubmed] | | | 35 |
Identification of a bioactive compound from Myrcianthes cysplatensis |
|
| DæAmico, E. and Barneche, S. and Cerdeiras, M.P. and Vaźquez, A. | | Pharmacognosy Journal. 2011; 3(25): 18-20 | | [Pubmed] | | | 36 |
Enhancement of the antibiotic activity of erythromycin by volatile compounds of Lippia alba (Mill.) N.E. Brown against Staphylococcus aureus |
|
| Veras, H.N.H. and Campos, A.R. and Rodrigues, F.F.G. and Botelho, M.A. and Coutinho, H.D.M. and Menezes, I.R.A. and Da Costa, J.G.M. | | Pharmacognosy Magazine. 2011; 7(28): 334-337 | | [Pubmed] | | | 37 |
Anti-staphylococcus activity of Uruguayan riverside forest plants |
|
| Barneche, S., Cerdeiras, M.P., Lucarini, R., Martins, C.H.G., Olivaro, C., Vazquez, A. | | Pharmacognosy Journal. 2011; 3(21): 69-71 | | [Pubmed] | |
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