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ORIGINAL ARTICLE
Year : 2010  |  Volume : 6  |  Issue : 22  |  Page : 142-144

Anticholinesterase activities of cold and hot aqueous extracts of F. racemosa stem bark


Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangotri, Mysore - 570 006, India

Correspondence Address:
Faiyaz Ahmed
Department of Studies in Food Science and Nutrition, University of Mysore, Manasagangotri, Mysore - 570 006
India
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Source of Support: University Grants Commission, New Delhi, India, for the financial assistance (F.31-278/2005), Conflict of Interest: None


DOI: 10.4103/0973-1296.62897

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The present study evaluated the anticholinesterase activity of cold and hot aqueous extracts of Ficus racemosa stem bark against rat brain acetylcholinesterase in vitro. Both the cold aqueous extract (FRC) and the hot aqueous extract (FRH) exhibited a dose dependent inhibition of rat brain acetylcholinesterase. FRH showed significantly higher ( p ≤ 0.001) cholinesterase inhibitory activity compared to FRC; however, both the extracts did not show 50% inhibition of AChE at the doses tested (200-1000 μg ml -1 ). The IC 50 values of 1813 and 1331 μg ml -1 were deduced for FRC and FRH, respectively (calculated by extrapolation using Boltzmann's dose response analysis).


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