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RESEARCH ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 19  |  Page : 11-14

Hypolipidemic activity of gum ghatti of Anogeissus latifolia


1 Department of Biotechnology, S.R.N.M. National College of Applied Sciences, Shivamogga, Karnataka 577201, India
2 Department of P.G. studies in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga-577203, Karnataka, India
3 Department of P G studies in Biotechnology and Bioinformatics, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shivamogga (D.) Karnataka 577541, India
4 Department of Pharmacology, National Pharmacy College, Shivamogga, Karnataka 577201, India

Correspondence Address:
C K Ramesh
Department of P.G. studies in Biotechnology, Sahyadri Science College (Autonomous), Kuvempu University, Shivamogga-577203, Karnataka
India
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Source of Support: None, Conflict of Interest: None


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Cardiovascular diseases are becoming an increasing problem worldwide and hypercholesterolemia has been correlated for coronary heart diseases. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia poses no side effects and is relatively cheap and locally available. In view of this, the present study was carried out to investigate the effect of gum ghatti of Anogeissus lalifolia on serum lipid levels of albino rats. Rats were made hyperlipidemic by the oral administration of cholesterol (400mg/kg body weight/day) along with cholic acid (50mg/kg) in coconut oil. The hypolipidemic effect was compared with control. The rats were divided into six groups of six animals each. In atherogenic diet induced hyperlipidemic model, the rats receiving treatment with gum ghatti at 250 mg/kg dosage showed significant reduction in serum triglyceride (82.75±0.63) only and there was no significant changes either in serum total cholesterol or elevation in HDL. Whereas, at 500 and 750 mg/kg dosage showed significant reduction in serum total cholesterol (72.85±0.60, 68.17±0.95) and serum triglyceride (78.92±0.34, 75.93±1.05). Further, the 750 mg/kg dose has also exhibited significant elevation in high density lipoprotein cholesterol (41.13±0.37).


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