| RESEARCH ARTICLE |
|
| Year : 2009 | Volume
: 5
| Issue : 17 | Page : 86-91 |
|
|
Tracheal relaxant effect of column chromatographic elutes of chloroform fraction of Adhatoda schimperiana leaves in guinea-pigs
Zelalem Petros1, Eyasu Makonnen1, Asfaw Debella2
1 Department of Pharmacology, Faculty of Medicine, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia
2 Department of Drug Research, Ethiopian Health and Nutrition Research Institute, P.O. Box 1242, Addis Ababa, Ethiopia
Correspondence Address:
Zelalem Petros
Department of Pharmacology, Faculty of Medicine, Addis Ababa University, P.O. Box 9086, Addis Ababa
Ethiopia
 Source of Support: None, Conflict of Interest: None  | Check |
|
|
|
Adhatoda schimperiana has been used in Ethiopian traditional medicine as a remedy for bronchial asthma. In the present study, tracheal relaxant effect of column chromatographic elutes (CCEs) of the chloroform fraction of the leaves of the plant was investigated on guinea-pigs. The intermediate polar CCE of the chloroform fraction showed tracheal relaxant effect as observed by a right-ward shift of the dose-response curve. The maximum response to histamine in presence of the intermediate polar CCE was significantly lower than that of the chloroform fraction (p<0.05). These results suggest that bioactivity-guided fractionation could show improved tracheal relaxant activity, and the alkaloid-rich fraction of the crude extract might be responsible for the claimed anti-asthmatic effect of the plant. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
Next article
