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Year : 2009  |  Volume : 5  |  Issue : 17  |  Page : 43-48

Effect of Argyreia speciosa extract on learning and memory paradigms in mice

1 AISSMS College of Pharmacy, Kennedy road, Pune-411 001, India
2 B.V.Pís Poona College of Pharmacy, Erandwane, Pune- 411038, India

Correspondence Address:
N S Vyawahare
AISSMS College of Pharmacy, Kennedy road, Pune-411 001
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Source of Support: None, Conflict of Interest: None

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The objective of the present study was to investigate the effect of hydroalcoholic extract of Argyreia speciosa (AS) on learning and memory paradigms in mice. Radial arm maze and morris water maze were the screening tests used to assess the activity of the extract. Piracetam served as a reference standard. The mice pretreated with AS 200 or AS 400 mg/kg or Piracetam (150mg/kg) showed a decrease in number of days required to make the mice learned, time taken to find food by the learned mice in radial arm maze. In morris water maze, the mice treated with the above mentioned doses showed a significant reduction in the number of days required to make the mice learned, escape latency of learned mice and number of circles completed before it escapes on to the platform. The results suggest facilitation of spatial learning and memory processes and thereby validated its traditional claim of being tonic in dullness of intellect.

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