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  Indian J Med Microbiol
 

Figure 8: Sketch map of synthesis of endothelin-1 mediated by transient receptor potential ion channel subfamily M member 8. Under the low temperature situation, activated TRPM8 channels induce Ca2+ influx which suppresses the expression of RACK-1 and promote activation of HIF-1. Activated HIF-1 enters the nucleus to initiate mRNA transcription of ET-1

Figure 8: Sketch map of synthesis of endothelin-1 mediated by transient receptor potential ion channel subfamily M member 8. Under the low temperature situation, activated TRPM8 channels induce Ca<sup>2+</sup> influx which suppresses the expression of RACK-1 and promote activation of HIF-1. Activated HIF-1 enters the nucleus to initiate mRNA transcription of ET-1