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  Indian J Med Microbiol
 

Figure 1: Inhibitory responses of Rg3 on release of CA produced by acetylcholine (left) and DMPP (right) in the perfused adrenal medulla of the rat. The release of CA evoked by an injection of ACh (5.32 mM) with a volume of 50 μL at 15-min intervals or by infusion of DMPP (100 μM) for 2 min at 20-min intervals was produced during perfusion of 3, 10, and 30 μM of Rg3 for 1.5 h as designated by bolt marks, respectively. The number in each parenthesis displays number of adrenal medulla. T-type bar on each column indicates SEM. Ordinate: The quantities of CA released in adrenal medulla (% of control). Abscissa: Collecting time of the perfusate (min). Significant difference was statistically analyzed by comparing the value of the control with individual dose-treatment group of Rg3. The collection of perfusates produced by ACh and DMPP was performed for 4 and 8 min, respectively. **P < 0.01. Rg3: Ginsenoside-Rg3; ns: Statistically nonsignificant; CA: Catecholamines; DMPP: 1,1-dimethyl-4-phenylpiperazinium; ACh: Acetylcholine; SEM: Standard errors of the mean

Figure 1: Inhibitory responses of Rg3 on release of CA produced by acetylcholine (left) and DMPP (right) in the perfused adrenal medulla of the rat. The release of CA evoked by an injection of ACh (5.32 mM) with a volume of 50 μL at 15-min intervals or by infusion of DMPP (100 μM) for 2 min at 20-min intervals was produced during perfusion of 3, 10, and 30 μM of Rg3 for 1.5 h as designated by bolt marks, respectively. The number in each parenthesis displays number of adrenal medulla. T-type bar on each column indicates SEM. Ordinate: The quantities of CA released in adrenal medulla (% of control). Abscissa: Collecting time of the perfusate (min). Significant difference was statistically analyzed by comparing the value of the control with individual dose-treatment group of Rg3. The collection of perfusates produced by ACh and DMPP was performed for 4 and 8 min, respectively. **<i>P</i> < 0.01. Rg3: Ginsenoside-Rg3; ns: Statistically nonsignificant; CA: Catecholamines; DMPP: 1,1-dimethyl-4-phenylpiperazinium; ACh: Acetylcholine; SEM: Standard errors of the mean