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  Indian J Med Microbiol
 

Figure 2: Effects of Valeriana on ethanol-withdrawal anxiety using elevated plus maze test. Ethanol abstinence significantly decreased (P < 0.01) time spend in open arm compared with ethanol-treated animals. Valeriana treatment to abstinent animals significantly (50 mg/kg, P < 0.001 and 100 mg/kg, P < 0.001) increased time spend in open arm compared with abstinent animals. Diazepam also significantly increased time spend in open arm over abstinent and ethanol-treated groups (P < 0.001). Animals treated with Valeriana in the presence of GABAA agonist spent significantly less time in the open arm (P < 0.001) compared with abstinent animals. Values expressed as mean ± standard error of the mean n = 6

Figure 2: Effects of <i>Valeriana</i> on ethanol-withdrawal anxiety using elevated plus maze test. Ethanol abstinence significantly decreased (<i>P</i> < 0.01) time spend in open arm compared with ethanol-treated animals. <i>Valeriana</i> treatment to abstinent animals significantly (50 mg/kg, <i>P</i> < 0.001 and 100 mg/kg, <i>P</i> < 0.001) increased time spend in open arm compared with abstinent animals. Diazepam also significantly increased time spend in open arm over abstinent and ethanol-treated groups (<i>P</i> < 0.001). Animals treated with <i>Valeriana</i> in the presence of GABA<sub>A</sub> agonist spent significantly less time in the open arm (<i>P</i> < 0.001) compared with abstinent animals. Values expressed as mean ± standard error of the mean <i>n =</i> 6