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  Indian J Med Microbiol
 

Figure 9: (a-e) Photomicrograph of liver section of mice showing the changes in cellular organization after three week of experiment (H and E), scale bar = 40 μm abbreviation marks- * (stick) central vein, . (open arrow) nucleus, . (arrow) sheet of hepatocytes, .(barred arrow) sinusoids. (a) Normal control group showed normal central vein, sheet of hepatocytes, and healthy nucleus are present, it is participated in normal glycogenolysis and gluconeogenesis synthesis therefore maintain glucose level and enzyme level- catalase, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and glucose-6-phosphate dehydrogenase inside the body. (b) Diabetic group representing destruction of central vein, de-leafing of sheet of hepatocyte and sinusoids cells therefore its loosed controlling power of glucose liver synthesis and increased glucose level and increased serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase inside the liver. (c) Insulin treated diabetic group appears almost similar to normal control mice but in central vein showed regaining of normal structure therefore its indicate insulin help to control of glucose synthesis and normalizing glucose levels. (d) Normal control treated with mulberry S-1708 which similar to control groups in cellular organization and reporting that S-1708 has no any side effect. (e) S-1708 Mulberry leaf treated with diabetic group is showing regain of cells structure such as central vein, nucleus, sheet of hepatocytes, sinusoids, after treatment of mulberry and performing good controlling of glucose level in blood and help insynthesis of glycogenolysis and gluconeogenesis inside the liver of mice

Figure 9: (a-e) Photomicrograph of liver section of mice showing the changes in cellular organization after three week of experiment (H and E), scale bar = 40 μm abbreviation marks- * (stick) central vein, . (open arrow) nucleus, . (arrow) sheet of hepatocytes, .(barred arrow) sinusoids. (a) Normal control group showed normal central vein, sheet of hepatocytes, and healthy nucleus are present, it is participated in normal glycogenolysis and gluconeogenesis synthesis therefore maintain glucose level and enzyme level- catalase, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and glucose-6-phosphate dehydrogenase inside the body. (b) Diabetic group representing destruction of central vein, de-leafing of sheet of hepatocyte and sinusoids cells therefore its loosed controlling power of glucose liver synthesis and increased glucose level and increased serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase inside the liver. (c) Insulin treated diabetic group appears almost similar to normal control mice but in central vein showed regaining of normal structure therefore its indicate insulin help to control of glucose synthesis and normalizing glucose levels. (d) Normal control treated with mulberry S-1708 which similar to control groups in cellular organization and reporting that S-1708 has no any side effect. (e) S-1708 Mulberry leaf treated with diabetic group is showing regain of cells structure such as central vein, nucleus, sheet of hepatocytes, sinusoids, after treatment of mulberry and performing good controlling of glucose level in blood and help insynthesis of glycogenolysis and gluconeogenesis inside the liver of mice