Figure 1: Curcumin (CU) solubility determined by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) after heat solubilization displaying masses from 250 to 700 (A) Mass spectra of only the matrix (α-cyano-4-hydroxycinnamic acid) (B) Mass spectra of curcumin preparation in water at 1 mg/ml obtained at room temperature (C) Mass spectra of curcumin preparation in water at 1 mg/ml obtained by heat treatment at 100°C for 10 min. The X-axis provides atomic weight values as mass divided by charge (z). Because the charge is 1, the mass remains unchanged for the values obtained. The Y-axis shows the number of ionized molecules. Asterisks indicate unassigned peaks. m/z 309, proton adduct of bisdemethoxycurcumin; m/z 361, sodium adduct of demethoxycurcumin; m/z 369, proton adduct of curcumin; m/z 379.2, α-cyano-4-hydroxycinnamic acid dimer (A) (Reproduced from Ref. 6 with permission from Mary Ann Liebert, Inc.).