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  Indian J Med Microbiol
 

Figure 4: Effect of shankhpushpi on ethanol intake. (a) Changes in the ethanol intake before and after treatment. Shankhpushpi- and diazepam-treated animals showed a significant decrease in ethanol intake compared with untreated ethanol consuming animals from day 24 (P < 0.001, n = 7) or after 4 days of treatment. In presence of GABAA blocker shankhpushpi showed little decrease in (P > 0.5) ethanol intake compared with ethanol-consuming animals till day 30. (b) Changes in ethanol intake on day 24 of the 30 days study. All treatment groups other than GABAA blocker + shankhpushpi group showed significant (P < 0.001) decrease in alcohol intake. (c) Change in the water intake before and after treatment. Shankhpushpi (200 mg/kg) and diazepam-treated animals showed a significant increase in water intake compared with untreated ethanol-consuming animals from day 24 (P < 0.001, n = 7) or after 4 days of treatment. In presence of GABAA blocker shankhpushpi did not show an increase (P > 0.5) in water intake compared with ethanol-consuming animals. (d) Change in alcohol intake on day 24 of the 30 days study. All treatment groups other than GABAA blocker + shankhpushpi group showed significant (P < 0.001) increase in water intake. Values represent mean ± standard error of the mean, n = 7

Figure 4: Effect of shankhpushpi on ethanol intake. (a) Changes in the ethanol intake before and after treatment. Shankhpushpi- and diazepam-treated animals showed a significant decrease in ethanol intake compared with untreated ethanol consuming animals from day 24 (<i>P</i> < 0.001, <i>n</i> = 7) or after 4 days of treatment. In presence of GABA<sub>A</sub> blocker shankhpushpi showed little decrease in (<i>P</i> > 0.5) ethanol intake compared with ethanol-consuming animals till day 30. (b) Changes in ethanol intake on day 24 of the 30 days study. All treatment groups other than GABA<sub>A</sub> blocker + shankhpushpi group showed significant (<i>P</i> < 0.001) decrease in alcohol intake. (c) Change in the water intake before and after treatment. Shankhpushpi (200 mg/kg) and diazepam-treated animals showed a significant increase in water intake compared with untreated ethanol-consuming animals from day 24 (<i>P</i> < 0.001, <i>n</i> = 7) or after 4 days of treatment. In presence of GABA<sub>A</sub> blocker shankhpushpi did not show an increase (<i>P</i> > 0.5) in water intake compared with ethanol-consuming animals. (d) Change in alcohol intake on day 24 of the 30 days study. All treatment groups other than GABA<sub>A</sub> blocker + shankhpushpi group showed significant (<i>P</i> < 0.001) increase in water intake. Values represent mean ± standard error of the mean, <i>n</i> = 7