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  Indian J Med Microbiol
 

Figure 1: Cucumis melo ssp. agrestis var. agrestis fruit extract ameliorates dyslipidemia, improves hyperglycemia and reduces adipogenesis. Syrian golden hamster fed with chow or high fat diet, either treated orally with fenofibrate (100 mg/kg) or Cucumis melo ssp. agrestis var. agrestis fruit extract (100 mg/kg) for 7 days. Animals were overnight fasted, blood was isolated and further serum was separated. (a) Triglyceride (b) total cholesterol (c) serum glucose (d) low-density lipoprotein-cholesterol, (e) high-density lipoprotein-cholesterol (f ) high-density lipoprotein-cholesterol/total cholesterol ratio. Mouse 3T3-L1 preadipocytes were differentiated into adipocytes with or without presence of various concentrations of Cucumis melo ssp. agrestis var. agrestis fruit extract (25, 50 100 μg/ml). Intracellular neutral lipids were stained with oil-red-O and absorbance was measured at 492 nm. MTT assay was performed in 3T3-L1 preadipocytes grown to confluence followed by incubation with Cucumis melo ssp. agrestis var. agrestis extracts (100-750 μg/ml) for 24 h. Cell viability was then determined by the MTT assay assay. (g) Cell viability using MTT assay (h) Oil-red-O staining in 3T3-L1 adipocytes. Values are means (n = 8), with their standard error of mean represented by vertical bars. Mean values were significantly different from the high fat diet diet-fed animals (one-way analysis of variance): *P < 0·05, **P < 0·001, ***P < 0.0001. *Denotes that the mean values are significantly different

Figure 1: <i>Cucumis melo ssp. agrestis var. agrestis fruit extract</i> ameliorates dyslipidemia, improves hyperglycemia and reduces adipogenesis. Syrian golden hamster fed with chow or high fat diet, either treated orally with fenofibrate (100 mg/kg) or <i>Cucumis melo ssp. agrestis var. agrestis fruit extract</i> (100 mg/kg) for 7 days. Animals were overnight fasted, blood was isolated and further serum was separated. (a) Triglyceride (b) total cholesterol (c) serum glucose (d) low-density lipoprotein-cholesterol, (e) high-density lipoprotein-cholesterol (f ) high-density lipoprotein-cholesterol/total cholesterol ratio. Mouse 3T3-L1 preadipocytes were differentiated into adipocytes with or without presence of various concentrations of <i>Cucumis melo ssp. agrestis var. agrestis fruit extract</i> (25, 50 100 μg/ml). Intracellular neutral lipids were stained with oil-red-O and absorbance was measured at 492 nm. MTT assay was performed in 3T3-L1 preadipocytes grown to confluence followed by incubation with <i>Cucumis melo ssp. agrestis var. agrestis</i> extracts (100-750 μg/ml) for 24 h. Cell viability was then determined by the MTT assay assay. (g) Cell viability using MTT assay (h) Oil-red-O staining in 3T3-L1 adipocytes. Values are means (<i>n</i> = 8), with their standard error of mean represented by vertical bars. Mean values were significantly different from the high fat diet diet-fed animals (one-way analysis of variance): *<i>P</i> < 0·05, **<i>P</i> < 0·001, <i>***P</i> < 0.0001. *Denotes that the mean values are significantly different