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  Indian J Med Microbiol
 

Figure 4: The effect of cryptotanshione (CT) on apoptosis and signal transducer and activators of transcription 3 (STAT3) in YD-15 cells. YD-15 cells were treated with 5, 10, or 15 μM of CT for 24 h. Cell proliferation was determined using a trypan blue exclusion assay. (a) The apoptotic effect of CT was determined by Western blot analysis using the antibodies against cleaved poly ADP ribose polymerase and cleaved caspase 3 (b) and 4'-6-diamidino-2-phenylindole staining. (c) p-STAT3 and STAT3 were analyzed by Western blot analysis. (d) Results are expressed as means ± standard deviation for triplicate experiments and significance (P < 0.05) compared with dimethyl sulfoxide-treated cells is indicated (*)

Figure 4: The effect of cryptotanshione (CT) on apoptosis and signal transducer and activators of transcription 3 (STAT3) in YD-15 cells. YD-15 cells were treated with 5, 10, or 15 μM of CT for 24 h. Cell proliferation was determined using a trypan blue exclusion assay. (a) The apoptotic effect of CT was determined by Western blot analysis using the antibodies against cleaved poly ADP ribose polymerase and cleaved caspase 3 (b) and 4'-6-diamidino-2-phenylindole staining. (c) p-STAT3 and STAT3 were analyzed by Western blot analysis. (d) Results are expressed as means ± standard deviation for triplicate experiments and significance (<i>P</i> < 0.05) compared with dimethyl sulfoxide-treated cells is indicated (*)