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  Indian J Med Microbiol
 

Figure 3: Effects of MA128 on the alpha-melanocyte stimulating hormone (α-MSH)-induced melanogenic activity in B16F10 cells. B16F10 cells were preincubated with or without 100 and 250 μg/ml MA128 for 12 h, and then simulated with 1 μM α-MSH for additional 36 h. (a) Accumulation of melanin in cells were observed under phase contrast microscope. Image magnification, ×200. Melanin content (b) and tyrosinase activity (c) were also determined. Arbutin (100 μg/ml) was used as positive control. Data are expressed as mean ± standard deviation of three independent experiments. *P < 0.05 versus untreated control, #P < 0.05 versus α-MSH stimulation

Figure 3: Effects of MA128 on the alpha-melanocyte stimulating hormone (α-MSH)-induced melanogenic activity in B16F10 cells. B16F10 cells were preincubated with or without 100 and 250 μg/ml MA128 for 12 h, and then simulated with 1 μM α-MSH for additional 36 h. (a) Accumulation of melanin in cells were observed under phase contrast microscope. Image magnification, ×200. Melanin content (b) and tyrosinase activity (c) were also determined. Arbutin (100 μg/ml) was used as positive control. Data are expressed as mean ± standard deviation of three independent experiments. <i>*P</i> < 0.05 versus untreated control, #<i>P</i> < 0.05 versus α-MSH stimulation