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  Indian J Med Microbiol
 

Figure 2: Chronograms showing circadian patterns for mouse body temperature at baseline (B + P) and 1 hour after oral Acn (30C or 6C) at six treatment times [in hours after lights on (HALO)]. 4-hour means ± SE from mice studied in LD 12:12 (6 mice/timepoint, 36 total) are shown with best-fitting 24-hour cosine. For time-effect, the fit of 24-hour cosine was significant at P < 0.05 for each series [see Table 2 for specifics]. An overall hyperthermia was significant following each Acn treatment in studies 3-6 separately or when the two studies of each dose were combined when compared with controls, while calculated acrophases (peaks) were significantly advanced, except for Study 3 (Acn 30C). Dark bar = 12-hour dark/activity span

Figure 2: Chronograms showing circadian patterns for mouse body temperature at baseline (B + P) and 1 hour after oral <i>Acn</i> (30C or 6C) at six treatment times [in hours after lights on (HALO)]. 4-hour means ± SE from mice studied in LD 12:12 (6 mice/timepoint, 36 total) are shown with best-fitting 24-hour cosine. For time-effect, the fit of 24-hour cosine was significant at <i>P</i> < 0.05 for each series [see Table 2 for specifics]. An overall hyperthermia was significant following each <i>Acn</i> treatment in studies 3-6 separately or when the two studies of each dose were combined when compared with controls, while calculated acrophases (peaks) were significantly advanced, except for Study 3 (<i>Acn</i> 30C). Dark bar = 12-hour dark/activity span